Severity of scratching may be a useful endpoint in clinical trials and practice across the gamut of pruritic disorders, according to a recent study. Researchers sought to validate and test the severity of scratching as an objective measure of itch (4-point ordinal scale ranging from 0 [not present] to 3 [very prominent] based on the observation of scratching lesions). They performed a prospective outpatient study using questionnaires and evaluations by a dermatologist in adults with atopic dermatitis (AD) (n=261). Severity of scratching best correlated with patient-reported global AD severity (Kendal’s Tau=0.336), Numeric Rating Scale (NRS) of itch in the past 24 hours (0.266) and 3 days (0.296). They found:
- Severity of scratching showed responsiveness over time.
- Patient’s experiencing ≥1-point improvement of scratching severity had significantly lower NRS-itch in the past 3 days (Wilcoxon rank sum test), 5-D itch scale, and Patient Oriented Eczema Measure (POEM) scores.
- There was a significant decrease in scratching severity for patients experiencing ≥4-point improvement of NRS-itch in the past 3 days (Fisher’s exact test), POEM, and Dermatology Life Quality Index (DLQI).
Udkoff J, Silverberg JI. Validation of scratching severity as an objective assessment for itch. [Published online ahead of print December 11, 2017]. J Invest Dermatol. doi:10.1016/j.jid.2017.11.028.
This Week's Must Reads
Health Care Screening, Skin Cancer Risk Link Found, JAMA Dermatology; ePub 2018 Dec 26; Drucker, et al
Vitamin D Linked with Eczema in Non-Hispanic Whites, Allergy; ePub 2018 Dec 27; Wei, Jaleel, et al
Mohs Surgery Beneficial for Melanoma of Head/Neck, Dermatolog Surg; ePub 2018 Dec 13; Demer, et al
Study: Vitiligo and Major Depression Disorder Linked, J Am Acad Dermatol; ePub 2018 Dec 5; Vallerand, et al
Habitual Nail Biting, Psychiatric Disorders Linked , Am J Clin Dermatol; 2018 Dec; Winebrake, et al
Must Reads in Atopic Dermatitis
Association Found Between AD and Suicidality, JAMA Dermatology; ePub 2018 Dec 12; Sandhu, et al
Anchoring Not Significant in Treatment of AD, J Dermatolog Treat; ePub 2018 Dec 3; Curry, et al
Unsafe Neighborhoods Linked with Higher AD Risk, Ann Allergy Asthma Immunol; ePub 2018 Oct 26; McKenzie, et al
Gestational Weight Gain, AD in Offspring Linked, J Allergy Clin Immunol; ePub 2018 Nov 8; Drucker, et al
Racial/Ethnic Differences Examined in Persistent AD, J Invest Dermatol; ePub 2018 Nov 8; Kim, et al