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Link Between AD and Autoimmune Disorders

J Am Acad Dermatol; ePub 2018 Oct 1; Narla, et al

Adults and children with atopic dermatitis (AD) had increased cutaneous and extra-cutaneous autoimmune disorders, which were associated with a considerable cost-burden, according to a recent study. Researchers conducted a cross-sectional study of the 2002–2012 National Inpatient Sample, including a 20% sample of all US hospitalizations (n=87,053, 155 adults and children). They found:

  • The prevalence of autoimmune disease was higher in adults (7.9% [7.3-8.5%] vs 5.7 [5.7-5.8%]) and children (2.0% [1.7-2.3%] vs 1.0% [0.9-1.1%]) with vs without AD.
  • In multivariable logistic regression models controlling for socio-demographics, adult and pediatric AD were associated with any autoimmune disorder.
  • In particular, AD was associated with 18 of 32 autoimmune disorders examined in adults and 12 of 24 examined in children, including disorders of the skin, endocrine, gastrointestinal, hematologic, and musculoskeletal systems.
  • AD patients hospitalized with any autoimmune disorder had higher cost of inpatient care with $2.5-$50 million excess annual costs.

Narla S, Silverberg JI. Association between atopic dermatitis and autoimmune disorders in US adults and children: A cross-sectional study. [Published online ahead of print October 1, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.09.025.