Atopic dermatitis (AD) places a heavy burden on patients, particularly those with moderate and severe AD, according to a recent study. A cross-sectional, population-based study of 602 adults was performed. AD severity was assessed using self-reported global AD severity, Patient-Oriented Eczema Measure (POEM), Patient-Oriented Scoring AD (POSCORAD), PO-SCORAD-itch, and sleep. Quality of life (QOL) was assessed using short-form (SF-)12 mental and physical health scores and Dermatology Life Quality Index (DLQI). Researchers found:
- Adults with AD reported higher proportions of having only fair/poor overall health (25.8% vs 15.8%), being somewhat/very dissatisfied with life (16.7% vs 11.4%), lower weighted mean [SD] SF-12 mental (45.9 [9.9] vs 50.9 [9.2]) and physical health subscores (53.0 [2.5] vs 53.5 [2.3]), and higher DLQI (4.9 [6.5] vs 1.1 [2.8]).
- In multivariable regression models adjusting for socio-demographics and multiple comorbid health disorders, there were significant stepwise decreases by AD severity (self-reported, POEM, PO-SCORAD) of overall health, life satisfaction, SF-12 mental health, and increases of DLQI scores.
- AD commonly limited lifestyle (51.3%), led to avoidance of social interaction (39.1%), and impacted activities (43.3%).
- The most burdensome AD symptoms were itch (54.4%), excessive dryness/scaling (19.6%), and red/inflamed skin (7.2%).
Silverberg JI, Gelfand JM, Margolis DJ, et al. Patient-burden and quality of life in atopic dermatitis in US adults: A population-based cross-sectional study. [Published online ahead of print July 16, 2018]. Ann Asthma Allergy Immunol. doi:10.1016/j.anai.2018.07.006.