Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

AD Patients’ Reactions to Personal Care Products

J Am Acad Dermatol; ePub 2018 Jul 24; Rastogi, et al

Atopic dermatitis (AD) patients had more positive patch test reactions to ingredients in personal care products, topical steroids, and antibiotics, according to a recent study. A retrospective chart review was performed of 502 adults (aged ≥18 years) who were patch-tested to an expanded allergen series from 2014-2017. Researchers found:

  • Overall, 108 (21.5%) had current AD and 109 (21.7%) had past AD.
  • Patients with vs without current AD had similar proportions of any positive (+/++/+++: 80 [74.1%] vs 254 [64.5%]), stronger (++/+++: 34 [31.5%] vs 102 [25.9%]), and irritant (56 [51.9%] vs 188 [47.7%]) patch test reactions.
  • AD patients had significantly higher rates of positive reactions to ingredients in personal care products and topical medications, including fragrance mix II, lanolin, bacitracin, cinnamal, budesonide, tixocortol, and chlorhexidine; relevance was established in >90% of these reactions.
  • Polysensitization occurred more commonly in patients with vs without AD (35 [32.4%] vs 75 [19.0%]).

Citation:

Rastogi S, Patel KR, Singam V, Silverberg SI. Allergic contact dermatitis to personal care products and topical medications in adults with atopic dermatitis. [Published online ahead of print July 24, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.07.017.

This Week's Must Reads

TNF inhibitor prices rose despite increased drug class competition, San-Juan-Rodriguez A et al. JAMA Intern Med. 2019 Feb 18. doi: 10.1001/jamainternmed.2018.7656

List of medications linked to drug-induced lupus expands, Arnaud L et al. Ann Rheum Dis. 2019 Feb 4. doi: 10.1136/annrheumdis-2018-214598

HLA Antigen Mismatch Linked with Skin Cancer Risk, JAMA Dermatology; ePub 2019 Jan 23; Gao, Twigg, et al

Poor Prognosis for Thin Ulcerated Melanomas Found, J Am Acad Dermatol; ePub 2019 Jan 14; Hawkins, et al

Association Between AD and Mental Health Disorders, Dermatitis; ePub 2018 Dec 18; Hsu, Smith, et al

Must Reads in Atopic Dermatitis

Association Between AD and Mental Health Disorders, Dermatitis; ePub 2018 Dec 18; Hsu, Smith, et al

Adult Atopic Dermatitis Profile Varies with Age, J Allergy Clin Immunol; ePub 2019 Jan 24; Zhou, et al

Association Found Between AD and Suicidality, JAMA Dermatology; ePub 2018 Dec 12; Sandhu, et al

Anchoring Not Significant in Treatment of AD, J Dermatolog Treat; ePub 2018 Dec 3; Curry, et al

Unsafe Neighborhoods Linked with Higher AD Risk, Ann Allergy Asthma Immunol; ePub 2018 Oct 26; McKenzie, et al