Atopic dermatitis (AD) patients had more positive patch test reactions to ingredients in personal care products, topical steroids, and antibiotics, according to a recent study. A retrospective chart review was performed of 502 adults (aged ≥18 years) who were patch-tested to an expanded allergen series from 2014-2017. Researchers found:
- Overall, 108 (21.5%) had current AD and 109 (21.7%) had past AD.
- Patients with vs without current AD had similar proportions of any positive (+/++/+++: 80 [74.1%] vs 254 [64.5%]), stronger (++/+++: 34 [31.5%] vs 102 [25.9%]), and irritant (56 [51.9%] vs 188 [47.7%]) patch test reactions.
- AD patients had significantly higher rates of positive reactions to ingredients in personal care products and topical medications, including fragrance mix II, lanolin, bacitracin, cinnamal, budesonide, tixocortol, and chlorhexidine; relevance was established in >90% of these reactions.
- Polysensitization occurred more commonly in patients with vs without AD (35 [32.4%] vs 75 [19.0%]).
Rastogi S, Patel KR, Singam V, Silverberg SI. Allergic contact dermatitis to personal care products and topical medications in adults with atopic dermatitis. [Published online ahead of print July 24, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.07.017.