Key clinical point: Fluorouracil cream was more effective in reducing AK lesions, compared with 3 other AK treatments in head-to-head trial.
Major finding: Nearly three-quarters of patients with actinic keratosis achieved treatment success with 5% fluorouracil.
Study details: A randomized trial compared four different field-directed treatments – fluorouracil, imiquimod, MAL-PDT, and ingenol mebutate – in 602 patients with AKs.
Disclosures: The study was supported by the Netherlands Organization for Health Research and Development. Five authors declared conference costs, advisory board fees, or trial supplies from private industry, including from manufacturers of some of the products in the study.
Jansen M et al. N Engl J Med. 2019; 380:935-46.
This Week's Must Reads
Must Reads in Actinic Keratosis
Actinic Keratosis Treatment Burden in Medicare , JAMA Dermatology; ePub 2018 Sep 19; Yeung, et al
Red Light ALA PDT Well Tolerated in AK Treatment, Photomed Laser Surg; ePub 2017 Dec 11; Paragh, et al
Cost of Managing AK Varies by Region, JAMA Dermatol; ePub 2017 Mar 1; Kirby, et al
Physician Wording Role in Seeking AK Treatment, JAMA Dermatol; ePub 2017 Jan 18; Berry, Butt, et al