Clinical Edge

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Fluorouracil Effective in Reducing AK Lesions

Key clinical point: Fluorouracil cream was more effective in reducing AK lesions, compared with 3 other AK treatments in head-to-head trial.

Major finding: Nearly three-quarters of patients with actinic keratosis achieved treatment success with 5% fluorouracil.

Study details: A randomized trial compared four different field-directed treatments – fluorouracil, imiquimod, MAL-PDT, and ingenol mebutate – in 602 patients with AKs.

Disclosures: The study was supported by the Netherlands Organization for Health Research and Development. Five authors declared conference costs, advisory board fees, or trial supplies from private industry, including from manufacturers of some of the products in the study.


Jansen M et al. N Engl J Med. 2019; 380:935-46.