Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Hormonal Antiandrogen Acne Treatment Examined

Am J Clin Dermatol; ePub 2018 Mar 20; Park, et al

Hormonal antiandrogen acne treatment (HAAT) is not typically used as a first-line systemic therapy in women with acne, according to a recent study. HAAT usage, however, is associated with shorter cumulative antibiotic durations and early HAAT initiation can decrease systemic antibiotic use in acne treatment. Researchers performed a retrospective study at an academic medical center of female patients receiving HAAT for acne (n=672) from January 2005 to October 2015. Data from a control group of female acne patients who never received HAAT were also collected. They found:

  • Out of all systemic medications for acne, antibiotics were used as first-line treatment in 39% of patients, combined oral contraceptives (COCs) in 12%, and spironolactone in 21%.
  • Mean antibiotic durations in patients who initiated HAAT for the first time at the study site (250.4 days) were significantly longer than in patients who received HAAT prior to presentation and continued HAAT at the study site (192.0 days).
  • A statistically significant inverse association was found between HAAT use and mean antibiotic duration.

Citation:

Park JH, Bienenfeld A, Orlow SJ, Nagler AR. The use of hormonal antiandrogen therapy in female patients with acne: A 10-year retrospective study. [Published online ahead of print March 20, 2018]. Am J Clin Dermatol. doi: 10.1007/s40257-018-0349-6.

This Week's Must Reads

HLA Antigen Mismatch Linked with Skin Cancer Risk, JAMA Dermatology; ePub 2019 Jan 23; Gao, Twigg, et al

Poor Prognosis for Thin Ulcerated Melanomas Found, J Am Acad Dermatol; ePub 2019 Jan 14; Hawkins, et al

Association Between AD and Mental Health Disorders, Dermatitis; ePub 2018 Dec 18; Hsu, Smith, et al

Nonsterile Gloves Safe for Skin Cancer Excisions, J Cosmet Dermatol; ePub 2019 Jan 20; Michener, et al

Adult Atopic Dermatitis Profile Varies with Age, J Allergy Clin Immunol; ePub 2019 Jan 24; Zhou, et al

Must Reads in Acne

FDA Approves Seysara for Severe Acne Vulgaris, Paratek Pharmaceuticals, Inc. news release; 2018 Oct 2

Prevalence of Acne Vulgaris Among Patients with HS, J Am Acad Dermatol; ePub 2018 Oct 1; Wertenteil, et al

Acne Successfully Treated with Laser Combination, Dermatolog Surg; ePub 2018 Jun 5; Bakus, et al

Large Acne Study of Twins Supports Genetic Link, J Drugs Dermatol; 2018 Apr 1; Suggs, Loesch, et al

Hormonal Antiandrogen Acne Treatment Examined, Am J Clin Dermatol; ePub 2018 Mar 20; Park, et al