Stage and anatomic site, but not thickness (ie, Breslow depth), race, or ethnicity, determine prognosis of mucosal melanomas, a recent study found. Therefore, considering the poor prognosis for all stages of mucosal melanoma, dermatologists should incorporate examination of the oropharynx and genitalia in the full body skin exam. Researchers analyzed 132,751 cases of melanoma, including 1,824 mucosal melanomas, diagnosed between 1994 and 2015 and reported to the California Cancer Registry. Kaplan-Meier survival analysis and Cox proportional hazards regression assessed the prognostic variables. They found:
- The 5-year relative survival for mucosal melanomas (27.64%) was significantly lower than for cutaneous melanomas (76.28%).
- Stage independently influenced survival, and thickness did not predict survival for neoplasms of known depth.
- Less common anatomic sites conferred worse prognoses (hazard ratio [HR] 1.93).
Altieri L, Eguchi M, Peng DH, Cockburn M. Predictors of mucosal melanoma survival in a population-based setting. [Published online ahead of print October 5, 2018]. J Am Acad Dermatol. doi:10.1016/j.jaad.2018.09.054.
This Week's Must Reads
Disease Burden of Atopic Dermatitis in the US, J Invest Dermatol; ePub 2018 Oct 30; Chiesa Fuxench, et al
Psoriasis Associated with Sexual Dysfunction, JAMA Dermatol; ePub 2018 Oct 10; Molina-Leyva, et al
Association Between Psoriasis and Suicide Examined, Dermatolog Ther; ePub 2018 Oct 12; Liang, et al
Study: More Than 85% of Surgeons Use Skin Hooks, Dermatolog Surg; ePub 2018 Oct 9; Clark, et al
FDA Approves Hyrimoz for Plaque Psoriasis, Sandoz news release; 2018 Oct 31
Must Reads in Melanoma
Melanoma Risk and Moderately Dysplastic Nevi, JAMA Dermatol; ePub Oct 10; Kim, Berry, et al
Predictors of Mucosal Melanoma Survival, J Am Acad Dermatol; ePub 2018 Oct 5; Altieri, et al
Follicular Involvement Frequent in Lentigo Maligna, J Am Acad Dermatol; ePub 2018 Sep 26; Connolly, et al
Sentinel Lymph Node Positivity Markers in Melanoma, J Am Acad Dermatol; ePub 2018 Sep 18; Conic, et al
Nevus Development Trajectory from Age 3 to 16 Years, JAMA Dermatology; ePub 2018 Sep 12; Asdigian, et al