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Quantitative ABCD Skin Lesion Parameters Assessed

Dermatol Online J; 2017 Aug; Glazer, Farberg, et al

Quantitative Asymmetry, Border irregularity, Color, and Diameter (qABCD) parameters for multispectral digital skin lesion analysis (MSDSLA) are repeatable and strongly correlate with the clinical ABCD features, a recent study found. Furthermore, qABCD characteristics provide an additional objective and reliable means of identifying pigmented skin lesions (PSLs) that need further evaluation to rule out malignant melanoma (MM) and, in combination with the clinical ABCDs, may allow for improved assessment when evaluating the malignant potential of PSLs. 1,632 benign and malignant [175 MM/High Grade Dysplastic Nevi (HGDN)] were evaluated for their qABCD parameters. Quantitative characteristics were correlated with the presence of clinical ABCD features identified by independent dermatologists. Researchers found:

  • qA, qB, qC, and qD had correlations of 78%, 73%, 76%, and 86%, respectively, for non-MM/HGDN lesions.
  • The correlations for qA, qB, qC, and qD for MM/HGDN lesions was 86.3%, 83%, 89%, and 89%, respectively.
  • All repeatability parameters were statistically significant.


Glazer AM, Farberg AS, Winkelmann RR, Tucker N, Rigel DS. Quantitative ABCD parameters measured by a multispectral digital skin lesion analysis device for evaluation of suspicious pigmented skin lesions strongly correlate with clinical ABCD observations. Dermatol Online J. 2017;(23)8:1. doi:doj_35997.

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