Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Patient-Reported Global Severity of Adult AD

Allergy; ePub 2017 Sep 14; Vakharia, Chopra, et al

Patient-reported atopic dermatitis (AD) severity appears to be sufficiently valid for assessing AD severity in the clinical and epidemiological setting, according to a recent study. Researchers performed a prospective dermatology practice-based study using questionnaires and evaluation by a dermatologist (n=265). They found:

  • At baseline and follow-up, patient-reported global AD severity significantly correlated with objective Scoring Atopic Dermatitis (oSCORAD, Spearman rho=0.56 and 0.49), SCORAD (0.64 and 0.56), Eczema Area Severity Index (EASI, 0.56 and 0.50), Body Surface Area (BSA, 0.52 and 0.45), Itch Numeric Rating Scale (NRS-itch, 0.60 and 0.53), Patient Oriented Eczema Measure (POEM, 0.50 and 0.48), and Dermatology Life Quality Index (DLQI, 0.50 and 0.49).
  • Patient-reported moderate and severe AD vs mild AD were associated with significantly higher oSCORAD, SCORAD, EASI, BSA, NRS-itch, POEM, and DLQI.
  • There was moderate concordance between patient-reported AD severity (mild, moderate, and severe) and previously developed severity strata for oSCORAD (kappa=0.39), SCORAD (kappa=0.47), EASI (kappa=0.37), NRS-itch (kappa=0.49), POEM (kappa=0.37), and DLQI (kappa=0.40).

Citation:

Vakharia PP, Chopra R, Sacotte, et al. Validation of patient-reported global severity of atopic dermatitis in adults. [Published online ahead of print September 14, 2017]. Allergy. doi:10.1111/all.13309.

This Week's Must Reads

Opioids and the Dermatology Medicare Population, JAMA Dermatology; ePub 2018 Feb 7; Cao, et al

Significant Care Costs Associated with Cellulitis, J Am Acad Dermatol; ePub 2018 Feb 7; St. John, et al

An Analysis of Adherence to Melanoma Treatment , J Clin Aesthet Dermatol; 2017 Dec; Reserva, et al

Underlying Disease Impact on Pyoderma Gangrenosum, J Am Acad Dermatol; ePub 2018 Feb 10; Kaffenberger, et al

FDA Approves Label Update for Cosentyx, Novartis news release; 2018 Feb 8

Must Reads in Atopic Dermatitis

Use of Antihistamines for AD Treatment Evaluated, J Am Acad Dermatol; ePub 2018 Jan 6; He, et al

Atopic Dermatitis Linked with Serious Infections, Ann Allergy Asthma Immunol; 2018 Jan; Narla, et al

Association Between AD and SCC Discovered, Int J Dermatol; ePub 2017 Dec 15; Cho, Davis, et al

Severity of Scratching Useful Assessment in Trials, J Invest Dermatol; ePub 2017 Dec 11; Udkoff, et al

Patient-Reported Global Severity of Adult AD, Allergy; ePub 2017 Sep 14; Vakharia, Chopra, et al