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Atopic Dermatitis Linked with Serious Infections

Ann Allergy Asthma Immunol; 2018 Jan; Narla, et al

Adults with atopic dermatitis (AD) had increased cutaneous, respiratory, multi-organ, and systemic infections, which were associated with a considerable cost burden, according to a recent study. Data from the 2002 to 2012 National Inpatient Sample were analyzed, including an approximately 20% sample of all US hospitalizations (n=72,108,077 adults). Prevalence of serious infections in hospitalized patients with vs without AD, length of stay, cost of care, and inpatient mortality secondary to serious infections were determined. Researchers found:

  • The prevalence of serious infections expressed as a percentage was higher in adults hospitalized with than in those without AD (42.1% vs 25.4%).
  • AD was associated with 32 of 38 infections examined.
  • Associated cutaneous infections included eczema herpeticum adjusted for other predictors: erysipelas and cellulitis.
  • Associated respiratory infections included aspergillosis and tuberculosis.
  • AD was associated with extracutaneous, multi-organ, and systemic infections, including infectious arthropathy, endocarditis, encephalitis, and methicillin-resistant Staphylococcus aureus infections.

Narla S, Silverberg JI. Association between atopic dermatitis and serious cutaneous, multiorgan and systemic infections in US adults. Ann Allergy Asthma Immunol. 2018;120(1):66-72.e11. doi:10.1016/j.anai.2017.10.019.

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