The Relevance of Clinical Pharmacology Studies of Basal Insulins to Primary Care
Pharmacokinetic (PK) and pharmacodynamic (PD) properties of drugs form the basis for the development of drugs used in everyday clinical practice, such as commonly used insulin products. PK measures the concentration of a drug in the body, and reflects the rates and amounts absorbed and processed. PD is the biologic effect of a drug in the body, including the time-course of when the biologic effect starts, peaks, and ends. While the determination of PK/PD parameters is important and foundational for the development of different insulin products, studies are often complex and can be difficult to translate into real-world clinical practice. In this round-table the speakers discuss PK/PD concepts, focusing on differentiation of basal insulin analogs and their use in individualized diabetes therapy.