Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Does Statin Use Reduce Influenza Vaccine Response?

Clin Infect Dis; ePub 2018 Oct 27; Havers, et al

Among adults in the US, influenza vaccine effectiveness (VE) against laboratory-confirmed illness was not affected by current statin use. Researchers compared influenza VE in statin users and nonusers aged ≥45 years enrolled in the US Vaccine Effectiveness Network study over 6 influenza seasons (2011‒2017). Participants presented to outpatient clinics with acute respiratory illness and were tested for influenza. Among the findings:

  • Among 11,692 eligible participants, 3,359 (30%) were statin users and 2,806 (24%) tested positive for influenza virus infection.
  • 78% of statin users and 60% of nonusers had received influenza vaccine.
  • Influenza VE was 36% among statin users and 39% among nonusers, after adjusting for influenza confounders.
  • Statin use did not modify the effect of vaccination on influenza when analyzed by type and subtype.

Citation:

Havers FP, Chung JR, Belongia EA, et al. Influenza vaccine effectiveness and statin use among adults in the United States, 2011–2017. [Published online ahead of print October 27, 2018]. Clin Infect Dis. doi:10.1093/cid/ciy780.

Commentary:

The fact that statin use does not decrease influenza vaccine efficacy is not surprising. There were studies in 2015 that proposed a decreased response to influenza vaccine in patients on statins. The study out of Emory found that patients in a large managed care organization were more likely to seek care for a respiratory illness if they had received the influenza vaccine. These studies had a lot of methodologic flaws, namely that patients who received the influenza vaccine tended to have more medical conditions. It does make sense that those who are on statins have a higher immunization rate since they will have at least 1 medical condition that they would be interacting with their physician. —John Russell, MD

This Week's Must Reads

AHA Statement: Accurate Measurement of BP, Hypertension; ePub 2019 Mar 4; Muntner, et al

Coffee Consumption & Plasma Biomarkers, Am J Clin Nutr; ePub 2019 Mar 5; Hang, et al

Is Adding Aspirin to Warfarin Therapy Beneficial? , JAMA Intern Med; ePub 2019 Mar 4; Schaefer, et al

Urinary Oxalate Excretion & Risk of CKD Progression, JAMA Intern Med; ePub 2019 Mar 4; Waikar, et al

Psychosocial Stress & CV Health in Older Women, Circulation; ePub 2019 Feb 28; Burroughs-Peña, et al

Must Reads in Vaccines

Vaccination for Prevention of Herpes Zoster, Ann Intern Med; ePub 2019 Feb 19; Prosser, et al

ACIP Updates Adult Immunization Schedule, Ann Intern Med; 2019 Feb 5; Kim, Hunter, et al

Influenza Vaccination Safety During Hospitalization, Mayo Clin Proc; ePub 2019 Jan 8; Tartof, et al

Acellular Pertussis Vaccine Is Safe & Effective, JAMA Pediatr; 2018 Nov; Wood, Nolan, et al

Influenza and Pertussis Vaccination in Pregnancy, Vaccine; ePub 2018 Nov 3; Wilcox, Bottrell, et al