Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Opioid-Related Adverse Events in Surgical Patients

JAMA Surg; ePub 2018 May 23; Shafi, et al

Opioid-related adverse drug events are common among patients undergoing hospital-based invasive procedures and are associated with worse patient clinical and cost outcomes, a recent study found. The retrospective study of clinical and administrative data included 135,379 adult patients (67.5% female) and examined the incidence of opioid-related adverse drug events (ORADEs) in patients undergoing hospital-based surgical and endoscopic procedures. Researchers found:

  • 14,386 (10.6%) patients in the study population experienced at least 1 ORADE.
  • Patients with ORADEs were more likely to be older, of white race/ethnicity, and male and have more comorbidities.
  • Patients with ORADEs received a higher total dose of opioids and for a longer duration.
  • ORADEs were associated with increased inpatient mortality, greater likelihood of discharge to another care facility, prolonged length of stay, high cost of hospitalization, and higher rate of 30-day readmission.

Citation:

Shafi S, Collinsworth AW, Copeland LA, et al. Association of opioid-related adverse drug events with clinical and cost outcomes among surgical patients in a large integrated health care delivery system. [Published online ahead of print May 23, 2018]. JAMA Surg. doi:10.1001/jamasurg.2018.1039.

This Week's Must Reads

Is Obesity Associated With Adverse CV Outcomes?, JAMA Netw Open; 2018 Nov 16; Riaz, et al

BMI & Risk of Postpregnancy T2D in Women with HDP , Diabetes Care; ePub 2018 Nov 19; Timpka, et al

Diabetes Outcomes in Patients by PCPs, NPs, or PAs, Ann Intern Med; ePub 2018 Nov 20; Jackson, et al

Traumatic Exposures & Health Issues in Older Women, JAMA Intern Med; ePub 2018 Nov 19; Gibson, et al

Risk of Opioid Overdose Hospitalizations , J Am Board Fam Med; 2018 Nov-Dec; Peters, et al

Must Reads in Pain

Risk of Opioid Overdose Hospitalizations , J Am Board Fam Med; 2018 Nov-Dec; Peters, et al

Cannabis Legalization & Opioid Therapy Compliance, Am J Med; ePub 2018 Nov 10; Lo, et al

Chronic Pain Among Suicide Decedents, Ann Intern Med; ePub 2018 Sep 11; Petrosky, et al

Pain and ED Use in Adults with Dementia, J Pain Symptom Manage; ePub 2018 Sep 14; Hunt, et al

Higher Optimism Predicts Lower Pain Reduction, J Pain; ePub 2018 Sep 13; Hinkle, Quiton