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Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Coffee Consumption & Plasma Biomarkers

Am J Clin Nutr; ePub 2019 Mar 5; Hang, et al

Coffee consumption is associated with favorable profiles of numerous biomarkers in key metabolic and inflammatory pathways, a new study found. Researchers investigated the associations of total, caffeinated, and decaffeinated coffee consumption with 14 plasma biomarkers. Data were derived from 2 cohorts of 15,551 women and 7,397 men, who provided detailed dietary data before blood draw and were free of diabetes, cardiovascular disease (CVD), or cancer at the time of blood draw. Multivariable linear regression was used to calculate the percentage difference of biomarker concentrations comparing coffee drinkers with nondrinkers, after adjusting for a variety of demographic, clinical, and lifestyle factors. They found:

  • Compared with nondrinkers, study participants who drank ≥4 cups of total coffee per day had lower concentrations of C-peptide, IGFBP-3, estrone, total estradiol, free estradiol, leptin, CRP, IL-6, and sTNFR-2.
  • These participants also had higher concentrations of SHBG, total testosterone, total adiponectin, and HMW adiponectin.
  • Results were similar for caffeinated and decaffeinated coffee.


Hang D, Kværner AS, Ma W, et al. Coffee consumption and plasma biomarkers of metabolic and inflammatory pathways in US health professionals. [Published online ahead of print March 5, 2019]. Am J Clin Nutr. doi:10.1093/ajcn/nqy295.

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