Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Prescription Medication Use & Depression

JAMA; 2018 Jun 12; Qato, Ozenberger, et al

The use of prescription medications that have depression as a potential adverse effect was common among US adults, with the use of multiple medications also associated with greater likelihood of simultaneous depression. This according to a cross-sectional survey study between 2005 and 2014 that measured the prevalence of any use and concurrent use of medications with a potential to cause depression and prevalence of depression. Researchers found:

  • 26,192 adults (mean age 46.2 years) were included in the study; 7.6% reported depression.
  • The estimated overall prevalence of US adults using medications with depression as a potential adverse effect was 37.2%.
  • The estimated prevalence of depression was 15% for those reporting use of ≥3 medications with depression as an adverse effect vs 4.7% for those not using such medications.

Citation:

Qato DM, Ozenberger K, Olfson M. Prevalence of prescription medications with depression as a potential adverse effect among adults in the United States. JAMA. 2018;319(22):2289–2298. doi:10.1001/jama.2018.6741.

This Week's Must Reads

Antibiotic Use Among US Older Adults, BMJ; ePub 2018 Jul 27; Olesen, Barnett, et al

Healthy Behaviors & Reduced Risk of Obesity , Mayo Clin Proc; ePub 2018 Jul 27; Shook, et al

Modifiable Risk Factors in New BP Categories, Am J Med; ePub 2018 Jul 26; Gu, Yue, et al

Psychological Screening for Youth with Abdominal Pain, Pediatrics; ePub 2018 Jul 25; Cunningham, et al

Low-Calorie Sweetened Beverages & Cardiometabolic Health, Circulation; ePub 2018 Jul 30; Johnson, et al

Must Reads in Mental Health

Psychological Screening for Youth with Abdominal Pain, Pediatrics; ePub 2018 Jul 25; Cunningham, et al

Prescription Medication Use & Depression, JAMA; 2018 Jun 12; Qato, Ozenberger, et al

Efficacy of CBT vs Education for Chronic Pain, Ann Intern Med; ePub 2018 Feb 27; Thorn, et al

Age at Menarche and Depression into Adulthood, Pediatrics; ePub 2017 Dec 26; Mendle, et al

Cognitive Training to Prevent Cognitive Decline, Ann Intern Med; ePub 2017 Dec 19; Butler, et al