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HIV Viral Suppression Trends in the US

Ann Intern Med; ePub 2018 Aug 21; Nance, et al

Across the US, HIV viral suppression rates improved dramatically from 1997 to 2015, due in part to improved antiretroviral therapy (ART); however, disparities among young and black people living with HIV (PLWH) remain. This according to a recent longitudinal observational cohort study that evaluated viral suppression trends in PLWH in 8 HIV clinics across the US. Including the relationship of associated factors, such as demographic characteristics and integrase strand transfer inhibitor (ISTI) use. Viral suppression rates from 1997 to 2015 were determined. Researchers found:

  • In tests among 31,930 PLWH, viral suppression increased from 32% in 1997 to 86% in 2015.
  • Being older and using an ISTI-based regimen were associated with lower odds of having a detectable viral load (VL), and black race was associated with higher odds.
  • Similar patterns were seen with continuous VL levels and with adjustment for adherence, substance use, or depression.


Nance RM, Delaney JC, Simoni JM, et al. HIV viral suppression trends over time among HIV-infected patients receiving care in the United States, 1997 to 2015: A cohort study. [Published online ahead of print August 21, 2018]. Ann Intern Med. doi:10.7326/M17-2242.