Clinical Edge

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Endometriosis is linked to adverse pregnancy outcomes

Key clinical point: Endometriosis is associated with a higher risk of adverse pregnancy conditions and outcomes.

Major finding: Women with endometriosis have a 46% higher risk of ectopic pregnancy, a 16% higher risk of preterm birth, and a 35% increased risk of gestational diabetes.

Study details: Analysis of data from 116,429 women aged 25-42 years enrolled in the Nurses Health Study II.

Disclosures: The study was supported by grants from the National Institutes of Health. Daniela A. Carusi, MD, received funding from UpToDate; Andrew W. Horne, MB, ChB, PhD, declared grant funding and consultancies with the European government and pharmaceutical sectors unrelated to the present study; Jorge E. Chavarro, MD, and Stacey A. Missmer, ScD, declared institutional funding from the NIH, and Dr. Missmer also received institutional funding from other funding bodies, as well as consulting fees. Leslie V. Farland, ScD, and the remaining coauthors had no relevant financial disclosures.