Clinical Edge

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Prediabetes Status & Lifestyle Modification

J Am Board Fam Med; 2019 Jan 4; Owei, et al

Communication of prediabetes status is associated with improvement in glucose tolerance, glycemia, and adiposity, a recent study found. The Pathobiology of Prediabetes in a Biracial Cohort (POP-ABC) study follow normoglycemic African American (AA) and European American (EA) offspring of parents with type 2 diabetes mellitus (T2D) for incident prediabetes. During 5.5 years of follow-up, 101 of 343 participants developed prediabetes and were notified, without any interventions. Data was compared from participants with incident prediabetes or normoglycemia (control) during POP-ABC who underwent retesting 18-months poststudy. Researchers found:

  • There were 73 participants in the prediabetes group and 73 in the control group.
  • The mean enrollment age was 48.7 years vs 48.3 years, with body mass index (BMI) of 31.1 vs 29.2 for prediabetes vs control groups, respectively.
  • Participants who were notified that they had developed incident prediabetes exhibited decreases in fasting plasma glucose and 2-hour plasma glucose levels, weight, and waist circumference when reassessed 18 months later.
  • The prediabetes group reported improved dietary and exercise habits compared with the control group.


Owei I, Umekwe N, Ceesay F, Dagogo-Jack S. Awareness of prediabetes status and subsequent health behavior, body weight, and blood glucose levels. J Am Board Fam Med. 2019;32(1):20-27. doi:10.3122/jabfm.2019.01.180242.