Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

BMI & Risk of Postpregnancy T2D in Women with HDP

Diabetes Care; ePub 2018 Nov 19; Timpka, et al

Women with a history of hypertensive disorders of pregnancy (HDP) who didn’t maintain a healthy weight in midlife were at increased risk for type 2 diabetes (T2D), a new study found. Researchers used data from the Nurses’ Health Study II to investigate the interaction between body mass index (BMI) and HDP history on the risk of T2D in women aged 45‒54 years. They found:

  • In total, 6,563 (11.7%) of 56,159 participants had a history of HDP and 1,341 women developed T2D during 436,333 person-years.
  • BMI was a strong risk factors for T2D regardless of HDP history.
  • However, there was evidence of an additive interaction between BMI and HDP for the risk of T2D.
  • The attributable proportion of risk due to interaction ranged from 0.12 in women who were overweight to 0.36 in women with obesity class I.


Timpka S, Stuart JJ, Tanz LJ, Hu FB, Franks PW, Rich-Edwards JW. Postpregnancy BMI in the progression from hypertensive disorders of pregnancy to type 2 diabetes. [Published online ahead of print November 19, 2018]. Diabetes Care. doi:10.2337/dc18-1532.

Must Reads in Diabetes

Testosterone Therapy to Prevent T2D in Men, Diabetes Care; ePub 2019 Mar 18; Yassin, et al

Patterns of Diabetes Screening During Office Visits, J Am Board Fam Med; 2019 Mar-Apr; Shealy, et al

Muscular Strength and Incidence of Type 2 Diabetes, Mayo Clin Proc; ePub 2019 Mar 11; Wang, et al

Insulin Management in Patients with T2D, Lancet; ePub 2019 Feb 22; Bergenstal, et al

Hospitalization Rates in Young-Onset Diabetes, Ann Intern Med; ePub 2019 Jan 15; Ke, Lau, et al