Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Is Obesity Associated With Adverse CV Outcomes?

JAMA Netw Open; 2018 Nov 16; Riaz, et al

Obesity is associated with type 2 diabetes (T2D) and coronary artery disease (CAD), but not with stroke, according to a systematic review and meta-analysis of nearly 1 million participants. Studies that used mendelian randomization methods to assess the association between any measure of obesity and the incidence of cardiovascular (CV) events and those that reported odds ratios (ORs) with 95% CIs estimated using an instrumental variable method were included. 5 studies were included in the final analysis. Researchers found:

  • Of 4,660 potentially relevant articles, 2,511 titles were screened; 7 were included in the systematic review, and 5 with 881,692 participants were eligible for inclusion in the meta-analysis.
  • Obesity was significantly associated with an increased risk of T2D (OR, 1.67) and CAD (OR, 1.20).
  • However, no association between obesity and stroke was found (OR, 1.02).

Citation:

Riaz H, Khan MS, Siddiqi TJ, et al. Association between obesity and cardiovascular outcomes. A systematic review and meta-analysis of mendelian randomization studies. JAMA Netw Open. 2018;1(7):e183788. doi:10.1001/jamanetworkopen.2018.3788.

This Week's Must Reads

AHA Statement: Accurate Measurement of BP, Hypertension; ePub 2019 Mar 4; Muntner, et al

Coffee Consumption & Plasma Biomarkers, Am J Clin Nutr; ePub 2019 Mar 5; Hang, et al

Is Adding Aspirin to Warfarin Therapy Beneficial? , JAMA Intern Med; ePub 2019 Mar 4; Schaefer, et al

Urinary Oxalate Excretion & Risk of CKD Progression, JAMA Intern Med; ePub 2019 Mar 4; Waikar, et al

Psychosocial Stress & CV Health in Older Women, Circulation; ePub 2019 Feb 28; Burroughs-Peña, et al

Must Reads in Cardiology

AHA Statement: Accurate Measurement of BP, Hypertension; ePub 2019 Mar 4; Muntner, et al

Is Adding Aspirin to Warfarin Therapy Beneficial? , JAMA Intern Med; ePub 2019 Mar 4; Schaefer, et al

Psychosocial Stress & CV Health in Older Women, Circulation; ePub 2019 Feb 28; Burroughs-Peña, et al

AHA Statement: CV Risk Reduction in Pediatrics, Circulation; ePub 2019 Feb 25; de Ferranti, et al

Sedentary Behaviors & CVD Risk in Older Women, Circulation; 2019 Feb 19; Bellettiere, et al