Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Dietary Cholesterol or Egg Consumption & CVD

JAMA; 2019 Mar 19; Zhong, Van Horn, et al

Higher consumption of dietary cholesterol or eggs is significantly associated with higher risk of incident cardiovascular disease (CVD) and all-cause mortality in a dose-response manner among US adults. Individual participant data were pooled from 6 prospective US cohorts in measuring dietary cholesterol (mg/day) or egg consumption (number/day). Researchers found:

  • 29,615 adults pooled from the 6 cohort studies with a median follow-up of 17.5 years were included.
  • Each additional 300 mg of dietary cholesterol consumed per day was significantly associated with a higher risk of incident CVD and all-cause mortality.
  • Each additional half an egg consumed per day was significantly associated with higher risk of incident CVD and all-cause mortality.

Citation:

Zhong VW, Van Horn L, Cornelis MC, et al. Associations of dietary cholesterol or egg consumption with incident cardiovascular disease and mortality. JAMA. 2019;321(11):1081–1095. doi:10.1001/jama.2019.1572.

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