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Seizures and Periodic Discharges in Traumatic Brain Injury

Ann Neurol; ePub 2016 Feb 28; Vespa, Tubi, et al

In patients with traumatic brain injury (TBI), seizures and pseudoperiodic discharges (PDs) are one mechanism for metabolic crisis, according to a study of 34 patients with TBI. Researchers found:

• 61% of patients with TBI experienced seizures or PDs.

• 42.9% of these seizures noted only on intracortal depth EEG and, in some cases, lasting many hours.

• Metabolic crisis, as measured by elevated cerebral microdialysis lactate/pyruvate ratio, occurred during seizures or PDs but not during electrically nonepileptic epochs.

Citation: Vespa P, Tubi M, Claasen J, et al. Metabolic crisis occurs with seizures and periodic discharges after brain trauma. [Published online ahead of print February 28, 2016]. Ann Neurol. doi:10.1002/ana.24606.