Mild-to-moderate obstructive sleep apnea (OSA), even when asymptomatic, is associated with increased risk of incident hypertension, but the strength of association significantly decreases with age, according to a recent study. Therefore, although older subjects with asymptomatic mild-to-moderate OSA are not at significant risk of developing hypertension, early detection and intervention, including improving metabolic indices, is especially warranted in young and middle-aged adults. From 1,741 adults of the Penn State Cohort, 744 adults without hypertension or severe OSA [ie, apnea/hypopnea index (AHI) ≥ 30 events/hour] were followed-up after 9.2 years. Mild OSA was defined as an AHI of 5 to 14.9 events/hour (n=71), while moderate OSA as an AHI of 15 to 29.9 events/hour (n=32). Researchers found:
- After adjusting for multiple potential confounders, mild-to-moderate OSA was significantly associated with increased risk of incident hypertension.
- Importantly, this association was modified by age; while strong in young and middle-aged adults, the association was lost in adults >60 years.
- Furthermore, the association of mild-to-moderate OSA with components of metabolic syndrome was strongest in young and middle-aged adults.
Vgontzas AM, Li Y, He F, et al. Mild-to-moderate sleep apnea is associated with incident hypertension: Age effect. [Published online ahead of print December 22, 2018]. Sleep. doi:10.1093/sleep/zsy265.
This Week's Must Reads
Global Burden of Brain and Other CNS Cancers, Lancet Neurol; ePub 2019 Feb 20; GBD 2016 Brain and Other CNS Cancer Collaborators
Ethnoracial Differences Found in Alzheimer Disease, Alzheimers Dement; ePub 2019 Feb 18; Santosa, et al
Must Reads in Sleep Medicine
Sleep-Disorder Breathing and Ischemic Stroke Linked, Stroke; ePub 2019 Feb 12; Brown, et al
Sleep Behavior Disorder, Clinical Progression in PD, Parkinsonism Relat Disord; ePub 2019 Jan 29; Duarte Folle, et al
Cost of Untreated Insomnia in Medicare Patients, Sleep; ePub 2019 Jan 12; Wickwire, Tom, et al
Mild-to-Moderate OSA Linked with Hypertension, Sleep; ePub 2018 Dec 22; Vgontzas, et al
Sleep Disturbance and Its Effect on Soldiers, Sleep; ePub 2018 Dec 17; Osgood, et al