Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Cerebral Cavernous Malformation in the Elderly

JAMA Neurol; ePub 2017 May 8; Flemming, et al

A recent prospective imaging study determined that the overall prevalence of older adults with cerebral cavernous malformation (CCM) is 0.46%. The findings and data from this study are important for determining the potential number of patients available for cohort studies and anticipated clinical trials in patients with CCM. Researchers included 4,721 participants aged 50 to 89 years who were enrolled between January 1, 2004, and December 15, 2015, in the Mayo Clinic Study of Aging, a longitudinal, population-based study. Participants were invited to undergo brain magnetic resonance imaging (MRI). Of total participants, 2,715 had an evaluable MRI. They found:

  • Of total participants who underwent MRI scans, 12 (0.44%) had CCM.
  • With the use of inverse probability weights to adjust for participation bias, the overall prevalence was 0.46%.
  • The age-adjusted prevalence was found to be 0.61% for the 50- to 59-year age group, 0.17% for the 60- to 69-year age group, 0.45% for the 70- to 79-year age group, and 0.58% for the 80- to 89-year age group.
  • The sex-adjusted prevalence was 0.41% for women and 0.51% for men.

Citation:

Flemming KD, Graff-Radford J, Aakre J, et al. Population-based prevalence of cerebral cavernous malformations in older adults. Mayo Clinic Study of Aging. [Published online ahead of print May 8, 2017]. JAMA Neurol. doi:10.1001/jamaneurol.2017.0439.

This Week's Must Reads

PD Global Burden More than Doubles, from 1990-2016, Lancet Neurol; ePub 2018 Oct 1; Dorsey, et al

Disparities Found in Dementia Medication Use for PD, JAMA Neurol, ePub 2018 Oct 1; Mantri, Fullard, et al

Gray Matter Abnormalities in Movement Disorders, Neurology; ePub 2018 Oct 10; Maurer, LaFaver, et al

Periodic Limb Movements in Sleep Increase with Age, Clin Neurophysiol; 2018 Nov; Leary, Moore IV, et al

Cognitive Ability Assessment Tool Proves Effective, Mov Disord; ePub 2018 Oct 10; Holden, Medina, et al

Must Reads in Rare Diseases

Treatment Outcomes Post-Surgery for Moyamoya Disease, J Neurol; ePub 2018 Sep 8; Kahn, Kaur, Stein, et al

FDA Approves Hizentra for CIDP Treatment, CSL Behring news release; 2018 Mar 16

Cerebral Cavernous Malformation in the Elderly , JAMA Neurol; ePub 2017 May 8; Flemming, et al