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Tramadol Use for Noncancer Pain Linked With Increased Hip Fracture Risk

Key clinical point: Tramadol, compared with other NSAIDs for chronic noncancer pain, was associated with increased hip fracture risk.

Major finding: Hip fracture incidence with tramadol vs. codeine was 3.7 vs. 2.9 per 1,000 person-years, respectively (HR, 1.28).

Study details: A large population-based cohort study including nearly 294,000 patients.

Disclosures: This study was supported by the National Institutes of Health, the National Natural Science Foundation of China, and the Postdoctoral Science Foundation of Central South University. The authors reported having no conflicts of interest.


Wei J et al. J Bone Miner Res. 2019 Feb 5. doi: 10.1002/jbmr.3935