Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Vitamin D May Be Therapeutic in MS Treatment

J Neurology; ePub 2018 Oct 3; McLaughlin, et al

Recent findings suggest that vitamin D supplementation may have a therapeutic role in the treatment of multiple sclerosis (MS). However, there is uncertainty with regard to the most appropriate dose, with high doses potentially being associated with worse outcomes. A systematic search of databases was performed to identify clinical trials assessing vitamin D in patients with relapsing–remitting MS. Studies were selected based on inclusion and exclusion criteria. 12 studies involving 950 patients were included in the final analysis. Researchers found:

  • No statistically significant difference was seen for any of the outcome measures.
  • There were non-significant trends in favor of vitamin D for all outcome measures, particularly when only placebo-controlled studies were included.
  • Dose comparison studies showed a significant increase in annualized relapse rate (mean difference 0.15) and non-significant trends of increased Expanded Disability Status Scale and gadolinium-enhancing lesions for the higher-dose arms.


McLaughlin L, Clarke L, Khalilidehkordi E, Butzkueven H, Taylor B, Broadley SA. Vitamin D for the treatment of multiple sclerosis: A meta-analysis. [Published online ahead of print October 3, 2018]. J Neurology. doi:10.1007/s00415-018-9074-6.

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MS Disease Burden: Which Symptoms Matter Most?, Mult Scler Relat Disord; 2018 Oct; Barin, et al

Retinal Layer Thickness and MS Conversion Risk, Mult Scler; ePub 2018 Dec 3; Filippatou, et al

Importance of Coping and QOL in People with MS, Int J MS Care; ePub 2018 Dec 6; Grech, et al