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Two Cognitive Tests for MS Have Different Strengths

Appl Neuropsychol Adult; ePub 2018 Apr 4; Costa, et al

The California Learning Verbal Test II (CVLT II) and the Open Trial-Selective Reminding Test (OT-SRT), used to assess learning in persons with multiple sclerosis (MS), are not equivalent tests, according to a recent comparison study. While the CVLT II appears to be sensitive to overall cognitive dysfunction, the OT-SRT is more sensitive to focal learning and memory impairments. 112 participants with MS performed both tests. All completed additional cognitive tests assessing information processing speed (IPS), working memory (WM), and executive functions (EF). All participants were identified as having impaired learning on the OT-SRT; however, only 38 participants (33.9%) were identified as having impaired learning on the CVLT II. The sample was thus divided into 2 groups, those who failed both tests (Fail-2) and those who failed only 1 (Fail-1). Researchers found:

  • The Fail-2 group showed poorer performance on EF, WM and IPS in comparison with the Fail-1 group.
  • On the CVLT II, the Fail-1 group showed a significantly greater improvement between trials 1 and 5, as compared with the Fail-2 group.

Citation:

Costa SL, DeLuca J, Costanza K, Chiaravalloti ND. Comparing the open trial – Selective reminding test results with the California Learning Verbal Test II in multiple sclerosis. [Published online ahead of print April 4, 2018]. Appl Neuropsychol Adult. doi:10.1080/23279095.2018.1448818.

This Week's Must Reads

Fully Automated Test Gauges Processing Speed in MS, MS Mult Scler; ePub 2018 Aug 6; Patel, Shen, et al

Inflammation and Disability in Progressive-Onset MS, JAMA Neurology; ePub 2018 Aug 6; Hughes, et al

Mental Health’s Impact on Falls in Patients with MS, Mult Scler Relat Disord; ePub 2018 Jul 26; Kalron, et al

House-Call-Based Practice Viable for Advanced MS, Int J MS Care; ePub 2018 Aug 7; Healey, Zabad, et al

Detection of Chronic Active MS Lesions on 3T MRI, AJNR Am J Neuroradiol; 2018 Jul; Absinta, et al

Must Reads in Multiple Sclerosis

Fully Automated Test Gauges Processing Speed in MS, MS Mult Scler; ePub 2018 Aug 6; Patel, Shen, et al

Inflammation and Disability in Progressive-Onset MS, JAMA Neurology; ePub 2018 Aug 6; Hughes, et al

Mental Health’s Impact on Falls in Patients with MS, Mult Scler Relat Disord; ePub 2018 Jul 26; Kalron, et al

House-Call-Based Practice Viable for Advanced MS, Int J MS Care; ePub 2018 Aug 7; Healey, Zabad, et al

Detection of Chronic Active MS Lesions on 3T MRI, AJNR Am J Neuroradiol; 2018 Jul; Absinta, et al