Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6) have particularly strong associations with multiple sclerosis (MS) and both viruses are typically acquired during childhood, decades before MS presents. In a recent study, however, none of these mutations were evident in EBV-positive samples from pediatric MS patients, whereas they were present in pediatric and adult controls, suggesting differential host-immune control of EBV in this pediatric MS cohort. In order to compare the frequency of EBV and HHV-6 in the saliva of a cohort of pediatric MS patients and age-matched controls, researchers enrolled 32 pediatric MS patients and 42 controls and evaluated saliva for HHV-6 u57 and EBV lmp-1 amplification by droplet digital polymerase chain reaction (ddPCR). They found:
- Pediatric MS patients did not differ from controls in the frequency or magnitude of salivary viral shedding.
- During the assessment of EBV positivity, distinct profiles emerged that correlated with target amplicon mutations.
Leibovitch EC, Major Lin C-T, Billoux BJ, Graves J, Waubant E, Jacobson S. Prevalence of salivary human herpesviruses in pediatric multiple sclerosis cases and controls. [Published online ahead of print March 23, 2018]. Mult Scler. doi:10.1177/1352458518765654.
This Week's Must Reads
Unilateral Thalamic Stimulation Improved Axial ET, Parkinsonism Relat Disord; ePub 2018 Sep 6; Mitchell, et al
Balance-Gait Disorder Risk Factor for Dementia in PD, J Parkinsons Dis; ePub 2018 Aug 13; Lichter, et al
Suicidal Ideation Prevalent in Persons with HD, J Huntingtons Dis; 2018 Jul 31; Wesson, et al
Everyday Functioning in Parkinson Disease Assessed, Parkinsonism Relat Disord; ePub 2018 Sep 1; Lopez, et al
Comparison of 2 DBS Methods for Essential Tremor, Mov Disord; ePub 2018 Sep 5; Fenoy, Schiess
Must Reads in Multiple Sclerosis
Cognitive Reserve Lessens Disability’s Effect on MS, Clin Neuropsychol; ePub 2018 Aug 28; Cadden, et al
Assessing Sexual Dysfunction in Patients with MS, Int J MS Care; 2018 Jul-Aug; Domingo, et al
Multiple Sclerosis Affects Memory Task Performance , Int J MS Care; 2018 Jul-Aug; Barbu, Berard, et al
Women with MS: Increased Risks During Pregnancy, Am J Epidemiol; ePub 2018 Aug 28; MacDonald, et al
Gait Variability, Energy Cost in Persons with MS, Am J Phys Med Rehab; 2018 Sep; Sebastião, et al