Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6) have particularly strong associations with multiple sclerosis (MS) and both viruses are typically acquired during childhood, decades before MS presents. In a recent study, however, none of these mutations were evident in EBV-positive samples from pediatric MS patients, whereas they were present in pediatric and adult controls, suggesting differential host-immune control of EBV in this pediatric MS cohort. In order to compare the frequency of EBV and HHV-6 in the saliva of a cohort of pediatric MS patients and age-matched controls, researchers enrolled 32 pediatric MS patients and 42 controls and evaluated saliva for HHV-6 u57 and EBV lmp-1 amplification by droplet digital polymerase chain reaction (ddPCR). They found:
- Pediatric MS patients did not differ from controls in the frequency or magnitude of salivary viral shedding.
- During the assessment of EBV positivity, distinct profiles emerged that correlated with target amplicon mutations.
Leibovitch EC, Major Lin C-T, Billoux BJ, Graves J, Waubant E, Jacobson S. Prevalence of salivary human herpesviruses in pediatric multiple sclerosis cases and controls. [Published online ahead of print March 23, 2018]. Mult Scler. doi:10.1177/1352458518765654.
This Week's Must Reads
Vegetable/Fruit Intake Benefits Cognitive Function, Neurology; ePub 2018 Nov 21; Yuan, Fondell, et al
Alzheimer Dementia and Age-Related Neuropathologies, Ann Neurol; ePub 2018 Nov 12; Boyle, Yu, et al
Kidney Function and Post-Stroke Mortality Examined, Stroke; ePub 2018 Nov 9; El Husseini, Fonarow, et al
Meditation May Help to Alleviate US Stroke Burden, J Stroke Cerebrovasc Dis; ePub 2018 Nov 24; Ambavane, et al
FDA Approves Firdapse for Rare Autoimmune Disorder, FDA news release; 2018 Nov 28
Must Reads in Multiple Sclerosis
Legal Cannabis Use Among Patients with MS, Mult Scler Relat Disord; ePub 2018 Nov 20; Weinkle, et al
Biomarker for Cognitive Decline in MS Examined, Mult Scler; ePub 2018 Nov 22; Schoonhoven, et al
Palliative Care Use Examined in Patients with MS, J Clin Neurosci; 2018 Dec; Lee, Yoo, Hua, et al
Predicting Unilateral Optic Nerve Lesions in MS, J Neuroophthalmol; 2018 Dec; Nolan, et al
Computer-Assisted Cognitive Tests, Minus Technicians, Mult Scler; ePub 2018 Nov 22; Wojcik, Rao, et al