Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Possible Delayed Diagnoses in Younger Patients, Men

Neurology; ePub 2018 Mar 16; Rotstein, Chen, et al

In a large, population-based multiple sclerosis (MS) cohort, researchers found stable incidence and increasing prevalence of MS. Furthermore, a spike in incidence in 2010 among younger patients and men at a time of widespread media coverage of MS suggests that these groups may be vulnerable to delayed diagnosis. Researchers identified MS cases from 1996 to 2013 by applying a validated algorithm to health administrative data. They found:

  • The prevalence of MS increased by 69% from 1.57 per 1,000 in 1996 (n=12,155) to 2.65 in 2013 (n=28,192).
  • Incidence remained relatively stable except for a spike in 2010, followed by a subsequent decline in 2011–2013, particularly among young people and men.
  • Mortality decreased by 33% from 26.7 per 1,000 to 18.0 per 1,000.
  • The incidence sex ratio was stable from 1996 to 2009, then declined in 2010, with partial rebound by 2013.

Rotstein DL, Chen H, Wilton AS, et al. Temporal trends in multiple sclerosis prevalence and incidence in a large population. [Published online ahead of print March 16, 2018]. Neurology. doi:10.1212/WNL.0000000000005331.

This Week's Must Reads

Proximity to Major Roadway, Stroke Risk Linked, Stroke; ePub 2018 Mar 14; Kulick, et al

Poor Sleep Quality and QOL in Patients with COPD, Sleep; ePub 2018 Mar 9; Zeidler, Martin, et al

ED Transfers for IS/TIA More than Doubled, 2006-14, Neurology; ePub 2018 Apr 4; George, Doyle, et al

Arterial Stiffness Major Risk Factor for Dementia, Neurology; ePub 2018 Mar 16; Hughes, et al

Reduced Contrast Sensitivity and Cognitive Decline, Ann Neurol; ePub 2018 Mar 8; Ward, Gelfand, et al

Must Reads in Multiple Sclerosis

Shortages Predicted in MS Neurologist Workforce , Int J MS Care; 2018 Jan/Feb; Halpern, Kane, et al

Characteristics of Episodic Hypothermia in MS, Mult Scler; ePub 2018 Mar 23; Toledano, et al

Presence of Herpesviruses in Pediatric MS Cases, Mult Scler; ePub 2018 Mar 23; Leibovitch, et al

Sex Ratio in MS Mortality Over 65 Years of Age, J Neurol; ePub 2018 Mar 21; Nakken, et al

Possible Delayed Diagnoses in Younger Patients, Men, Neurology; ePub 2018 Mar 16; Rotstein, Chen, et al