Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Multiple Sclerosis Affects Memory Task Performance

Int J MS Care; 2018 Jul-Aug; Barbu, Berard, et al

People with multiple sclerosis (MS) performed worse on memory tasks at baseline compared with controls, according to a recent study. 32 individuals with early-phase relapsing-remitting MS with mild physical disability and disease duration <10 years, plus 32 controls, were recruited. At baseline and after 3 years, participants completed neuropsychological tests evaluating several cognitive domains. The cognitive reserve (CR) was assessed via a cognitive reserve index (CRI) using educational levels and North American Adult Reading Test scores. Change in cognition was assessed using a reliable change index. Researchers found:

  • At baseline, people with MS performed worse than controls on visual memory.
  • There were no significant group differences on information processing speed, learning, language, and executive functions.
  • Although people with MS and controls improved over time, beyond practice effects, people with MS improved less than controls.
  • Most cognitive domains showed no change over time, and CRI was not a significant predictor in the regression model.


Barbu RM, Berard JA, Gresham LM, Walker LAS. Longitudinal stability of cognition in early-phase relapsing-remitting multiple sclerosis. Does cognitive reserve play a role? Int J MS Care. 2018;20(4):173–179. doi:10.7224%2F1537-2073.2016-073.

This Week's Must Reads

Cortical Dynamics in Essential Tremor Examined, Mov Disord; ePub 2018 Oct 21; Roy, et al

Distinguishing PD from PSP Through Biomarker, J Parkinsons Dis; 2018 Oct; Bottero, et al

Self-Reported Activity in Veterans with PD is Low, Parkinsonism Relat Disord; ePub 2018 Oct 23; Mantri, et al

End-Of-Life Experiences in Dementia with Lewy Bodies, J Am Geriatr Soc; ePub 2018 Oct 6; Armstrong, et al

First-Degree Kin of Patients with ET and Cognition, Parkinsonism Relat Disord; ePub 2018 Oct 30; Meyers, et al

Must Reads in Multiple Sclerosis

Link Between Fatigue and Fatigability Found in MS, Mult Scler Relat Disord; ePub 2018 Oct 27; Cehelyk, et al

How Patients with MS Use Various Coping Strategies, Mult Scler Relat Disord; ePub 2018 Oct 22; Holland, et al

Role of Family Planning in Women with MS, Front Neurol; ePub 2018 Oct 10; Kamm, et al

Urban Air Quality and Links to Pediatric MS, Ann Clin Transl Neurol; ePub 2018 Sep 27; Lavery, et al

DMT Cost Sharing Can Help Improve DMT Access in MS, Value Health; 2018 Sep; Shao, Stoecker, et al