Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Multiple Sclerosis Affects Memory Task Performance

Int J MS Care; 2018 Jul-Aug; Barbu, Berard, et al

People with multiple sclerosis (MS) performed worse on memory tasks at baseline compared with controls, according to a recent study. 32 individuals with early-phase relapsing-remitting MS with mild physical disability and disease duration <10 years, plus 32 controls, were recruited. At baseline and after 3 years, participants completed neuropsychological tests evaluating several cognitive domains. The cognitive reserve (CR) was assessed via a cognitive reserve index (CRI) using educational levels and North American Adult Reading Test scores. Change in cognition was assessed using a reliable change index. Researchers found:

  • At baseline, people with MS performed worse than controls on visual memory.
  • There were no significant group differences on information processing speed, learning, language, and executive functions.
  • Although people with MS and controls improved over time, beyond practice effects, people with MS improved less than controls.
  • Most cognitive domains showed no change over time, and CRI was not a significant predictor in the regression model.


Barbu RM, Berard JA, Gresham LM, Walker LAS. Longitudinal stability of cognition in early-phase relapsing-remitting multiple sclerosis. Does cognitive reserve play a role? Int J MS Care. 2018;20(4):173–179. doi:10.7224%2F1537-2073.2016-073.

This Week's Must Reads

Hospital Readmission After Seizure Discharge, Neurology; ePub 2018 Dec 21; Blank, et al

VP Shunts and Post-Operative Complications Assessed, J Stroke Cerebrovasc Dis; ePub 2018 Dec 20; Linzey, et al

Disparities in Inter-Hospital Helicopter Transport, J Stroke Cerebrovasc Dis; ePub 2018 Dec 11; Sarrazin, et al

Mild-to-Moderate OSA Linked with Hypertension, Sleep; ePub 2018 Dec 22; Vgontzas, et al

Aspirin Reduces Stroke Risk in Women with Prior HDP, Neurology; ePub 2018 Dec 26; Miller, Boehme, et al

Must Reads in Multiple Sclerosis

Prevalence of Asthma in Persons with MS, Mult Scler Relat Disord; ePub 2018 Dec 11; Hill, et al

Normal-Appearing White Matter in MS Examined, Neuroradiology; ePub 2018 Dec 12; Yu, et al

MS Disease Burden: Which Symptoms Matter Most?, Mult Scler Relat Disord; 2018 Oct; Barin, et al

Retinal Layer Thickness and MS Conversion Risk, Mult Scler; ePub 2018 Dec 3; Filippatou, et al

Importance of Coping and QOL in People with MS, Int J MS Care; ePub 2018 Dec 6; Grech, et al