Multiple sclerosis (MS) is associated with an increased risk of divorce among men, but not women, according to a recent study. Patient diagnosed with MS between 1975 and 2012 were identified in a nationwide disease-specific register and matched with general population controls based on age, sex, region of residency, and marital status. The final sample comprised 3,998 patients and 15,992 general population controls (mean age 44 years; 73% female). Mean follow-up was 10 years (range: 1–37 years). Researchers found:
- Unadjusted Kaplan-Meier failure functions revealed no significant differences in the cumulative incidence proportion of divorce between patients and controls, or women with MS and female controls.
- In contrast, men with MS were estimated to have a notably higher incidence of divorce compared with male controls.
- Cox proportional-hazards model outcomes showed that men with MS had a 21% higher risk (HR: 1.21) of divorce across follow-up compared with male controls when controlling for age, region of residency, and year of diagnosis.
- No significant adjusted risk increase was found for women with MS.
Landfeldt E, Castelo-Branco A, Svedbom A, Löfroth E, Kavaliunas, Hillert J. The long-term impact of multiple sclerosis on the risk of divorce. [Published online ahead of print July 3, 2018]. Mult Scler Relat Disord. doi:10.1016/j.msard.2018.07.002.
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