Clinical Edge

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MS Disease Burden: Which Symptoms Matter Most?

Mult Scler Relat Disord; 2018 Oct; Barin, et al

While health-related quality of life (HRQoL) at population level is most affected by balance problems, spasticity, and depression in relapsing-remitting multiple sclerosis (RRMS), the biggest HRQoL losses in progressive MS (PMS) are caused by spasticity, paralysis, weakness, and pain, according to a recent study. Researchers included 855 MS registry participants with RRMS or PMS. HRQoL was measured with the EuroQol 5-Dimension EQ-5D-index and EQ-Visual Analogue Scale (EQ-VAS) on 0–100% scales. They found:

  • 611 participants with RRMS and 244 with PMS were included.
  • In RRMS, gait (−6.5%) and balance problems (−5.1%) had the largest EQ-5D-index reductions, and were also important at the population level (frequencies 45% and 52%).
  • Fatigue, depression, and spasticity (frequencies 74.1%, 31%, 38%) also contributed to the population disease burden.
  • In PMS, spasticity, paralysis, and bowel problems had the largest impact on EQ-5D-index, both at the individual and population levels.
  • The largest impact on EQ-VAS at population level was associated in RRMS with balance problems, depression, dizziness, and spasticity, while in PMS with weakness, pain, and paralysis.
Citation:

Barin L, Salmen A, Disanto G, et al. The disease burden of multiple sclerosis from the individual and population perspective: Which symptoms matter most? Mult Scler Relat Disord. 2018;25:112–121. doi:10.1016/j.msard.2018.07.013.