Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Lifetime Exposure to UVR and MS Risk in the US

Mult Scler; ePub 2018 Jun 1; Gallagher, et al

The findings of a recent study are consistent with the hypothesis that ultraviolent radiation (UVR) exposure reduces multiple sclerosis (MS) risk and may ultimately suggest prevention strategies. Participants (n= 39,801) in the third and fourth surveys of the US Radiologic Technologists (USRT) Cohort Study eligible for analysis provided complete residential histories and reported MS diagnoses. MS-specialized neurologists conducted medical record reviews and confirmed 148 cases. Residential locations throughout life were matched to satellite data from NASA’s Total Ozone Mapping Spectrometer (TOMS) project to estimate UVR dose. Researchers found:

  • MS risk increased as average lifetime levels of UVR exposures in winter decreased.
  • The effects were consistent across age groups <40 years.
  • There was little indication that low exposures during summer or at older ages were related to MS risk.

Gallagher LG, Ilango S, Wundes A, et al. Lifetime exposure to ultraviolet radiation and the risk of multiple sclerosis in the US radiologic technologists cohort study. [Published online ahead of print June 1, 2018]. Mult Scler. doi:10.1177/1352458518783343.

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