Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

CBT for Treatment of Depression in MS

Int J MS Care; ePub 2018 Jun 25; Ratajska, et al

Depression is common in multiple sclerosis (MS), affecting up to 50% of patients at some point in their lifetime. Although the rate of depression in MS is higher than that of the general population and that of patients with other chronic medical conditions, depression in MS is underdiagnosed and undertreated, according to a recent review. Antidepressants are used empirically in the management of MS-related depression, but evidence specifically demonstrating the efficacy of these medications in MS patients is sparse.

However, considerable work suggests that psychological interventions, such as cognitive behavioral therapy (CBT), may be effective in the management of depression in MS. Recently, there has been an expansion of computerized adaptations of CBT, allowing patients to complete therapy sessions remotely via online programs. This review discusses the current understanding of depression in MS and the role of CBT in its management, focusing on recent developments in computerized formats for CBT. 4 computerized CBT programs that have been previously tested in MS patients are described: Deprexis, MoodGYM, Beating the Blues, and MS Invigor8.


Ratajska A, Zurawski J, Healy B, Glanz BI, from Partners Multiple Sclerosis Center, Brigham and Women’s Hospital, Boston, MA. Computerized cognitive behavioral therapy for treatment of depression in multiple sclerosis: A narrative review of current findings and future directions. [Published online ahead of print June 25, 2018]. Int J MS Care. doi:10.7224/1537-2073.2017-094.

This Week's Must Reads

Examining Brain Markers for Late-Onset Epilepsy, Neurology; ePub 2019 Jan 25; Johnson, et al

Hearing Loss Linked Cognitive Decline Risk in Men, Alzheimers Dement; ePub 2019 Jan 29; Curhan, et al

Brain Cholesterol Metabolism and PD Examined, Mov Disord; ePub 2019 Jan 25; Huang, et al

Sleep Behavior Disorder, Clinical Progression in PD, Parkinsonism Relat Disord; ePub 2019 Jan 29; Duarte Folle, et al

Spontaneous Subarachnoid Hemorrhage During Pregnancy, J Stroke Cerebrovasc Dis; ePub 2019 Jan 30; Limaye, et al

Must Reads in Multiple Sclerosis

Prevalence of Asthma in Persons with MS, Mult Scler Relat Disord; ePub 2018 Dec 11; Hill, et al

Normal-Appearing White Matter in MS Examined, Neuroradiology; ePub 2018 Dec 12; Yu, et al

MS Disease Burden: Which Symptoms Matter Most?, Mult Scler Relat Disord; 2018 Oct; Barin, et al

Retinal Layer Thickness and MS Conversion Risk, Mult Scler; ePub 2018 Dec 3; Filippatou, et al

Importance of Coping and QOL in People with MS, Int J MS Care; ePub 2018 Dec 6; Grech, et al