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Synaptic Pruning Deficits May Cause Tremor in Essential Tremor

Key clinical point: Using a mouse model and human subjects, researchers investigated the molecular and physiological factors that contribute to tremor in essential tremor.

Major finding: Cerebellar oscillatory indexes were correlated with tremor scores in patients with essential tremor.

Study details: A study of a mouse model of essential tremor, 20 patients with essential tremor, and 20 controls.

Disclosures: The research was funded by grants from the National Institutes of Health, the Parkinson’s Foundation, the International Essential Tremor Foundation, the Ministry of Science and Technology in Taiwan, and the National Taiwan University Hospital. The authors declared that they had no competing interests.


Pan M-K et al. Sci Transl Med. 2020;12:eaay1769. doi: 10.1126/scitranslmed.aay1769.