Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Susceptibility MRI Reveals PD Progression Patterns

Mov Disord; ePub 2018 May 14; Du, Lewis, et al

Susceptibility MRI revealed distinct patterns of Parkinson disease (PD) progression in the substantia nigra pars compacta and substantia nigra pars reticulata, according to a recent study. These findings may resolve past controversies and have implications in the pathophysiological processes during PD progression. 72 PD patients and 62 controls were studied at both baseline and after 18 months with MRI. R2* and quantitative susceptibility mapping values from the substantia nigra pars compacta and substantia nigra pars reticulata were calculated. Researchers found:

  • At baseline, R2* and quantitative susceptibility mapping were higher in both the substantia nigra pars compacta and substantia nigra pars reticulata in all PD patients.
  • Longitudinally, the substantia nigra pars compacta R2* showed a faster increase in PD compared with controls (time × group), whereas quantitative susceptibility mapping did not.
  • Baseline substantia nigra pars compacta R2* was higher in all PD subgroups (group), but showed a significantly faster increase only in later‐stage PD (time × group) that correlated with changes in nonmotor symptoms (r = 0.746).
Citation:

Du G, Lewis MM, Sica C, et al. Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients. [Published online ahead of print May 14, 2018]. Mov Disord. doi:10.1002/mds.27318.

This Week's Must Reads

Quality of Life Varies in the Early Stages of MS, Disabil Health J; ePub 2018 May 31; Strober

Molecular Signature of EBV in MS Brain Lesions, Neurol Neuroimmunol Neuroinflamm; 2018 Jul; Moreno, et al

3D-FLAIR Detects Highest Infratentorial MS Lesions, Clin Imaging; 2018 Sep-Oct; Wang, Uribe, et al

Examining the Progression of Fatigue in MS, Mult Scler; 2018 Jun; van der Vuurst de Vries, et al

Psychosocial Adjustment in People with MS, Int J MS Care; 2018 May/Jun; Grech, et al

Must Reads in Movement Disorders

Tourette Syndrome, Tic Disorders, and Education, JAMA Neurology; ePub 2018 May 29; Pérez-Vigil, et al

RLS with PLMS More Common in Elderly Persons, Sleep; ePub 2018 Jun 1; Doan, Koo, Ogilvie, et al

Predicting Alpha-Synuclein Pathology Pre-Mortem, Parkinsonism Relat Disord; ePub 2018 May 17; Shprecher, et al

Excessive Daytime Sleepiness: Early Feature of DLB , Parkinsonism Relat Disord; 2018 May; Kasanuki, et al

HIV in HD Linked with Earlier Age of Symptom Onset, J Huntingtons Dis; 2018 Jun 1; Schultz, et al