Susceptibility MRI revealed distinct patterns of Parkinson disease (PD) progression in the substantia nigra pars compacta and substantia nigra pars reticulata, according to a recent study. These findings may resolve past controversies and have implications in the pathophysiological processes during PD progression. 72 PD patients and 62 controls were studied at both baseline and after 18 months with MRI. R2* and quantitative susceptibility mapping values from the substantia nigra pars compacta and substantia nigra pars reticulata were calculated. Researchers found:
- At baseline, R2* and quantitative susceptibility mapping were higher in both the substantia nigra pars compacta and substantia nigra pars reticulata in all PD patients.
- Longitudinally, the substantia nigra pars compacta R2* showed a faster increase in PD compared with controls (time × group), whereas quantitative susceptibility mapping did not.
- Baseline substantia nigra pars compacta R2* was higher in all PD subgroups (group), but showed a significantly faster increase only in later‐stage PD (time × group) that correlated with changes in nonmotor symptoms (r = 0.746).
Du G, Lewis MM, Sica C, et al. Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients. [Published online ahead of print May 14, 2018]. Mov Disord. doi:10.1002/mds.27318.
This Week's Must Reads
Fully Automated Test Gauges Processing Speed in MS, MS Mult Scler; ePub 2018 Aug 6; Patel, Shen, et al
Inflammation and Disability in Progressive-Onset MS, JAMA Neurology; ePub 2018 Aug 6; Hughes, et al
Mental Health’s Impact on Falls in Patients with MS, Mult Scler Relat Disord; ePub 2018 Jul 26; Kalron, et al
House-Call-Based Practice Viable for Advanced MS, Int J MS Care; ePub 2018 Aug 7; Healey, Zabad, et al
Detection of Chronic Active MS Lesions on 3T MRI, AJNR Am J Neuroradiol; 2018 Jul; Absinta, et al
Must Reads in Movement Disorders
Index Finger Pointing Observed in Movement Disorders, Front Neurol; ePub 2018 Jul 4; Vives-Rodriguez, et al
Contact Sports Linked with Lewy Body Pathology, J Neuropathol Exp Neurol; ePub 2018 Jul 25; Adams, et al
Predictors of Worsening HRQL in Parkinson Disease, Parkinsonism Relat Disord; ePub 2018 Jul 2; Margolius, et al
Patients with PD Having Lumbar Surgery: Greater LOS, Parkinsons Dis; ePub 2018 Jun 27; Steinberger, et al
DBS Surgery with General Anesthesia Safe, Effective , J Neurosurg; 2018 Aug; Chen, Mirzadeh, Chapple, et al