Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Is RLS Associated with Premotor Symptoms of PD?

J Neurol Sci; ePub 2018 Sep 1; Iwaki, Hughes, et al

There were moderate associations between the presence of restless legs syndrome (RLS) and increased odds of having constipation and possible REM sleep behavior disorder (pRBD). This according to a recent, large-scale, longitudinal study that aimed to investigate if transient or continuous/recurrent RLS identified by questionnaire are associated with the premotor symptoms of Parkinson disease (PD). The study population comprised 16,636 men in the Health Professional Follow-Up Study, who answered questions regarding RLS symptoms in both 2002 and 2008, and were not diagnosed with PD. Outcomes were self-reported constipation, pRBD in 2012, and smell identification test score in 2014. Researchers found:

  • RLS was associated with increased odds of constipation, but only continuous/recurrent RLS status was associated with higher odds of having pRBD.
  • RLS was not significantly associated with olfactory scores.


Iwaki H, Hughes KC, Gao X, Schwarzschild MA, Ascherio A. The association between restless legs syndrome and premotor symptoms of Parkinson's disease. [Published online ahead of print September 1, 2018]. J Neurol Sci. doi:10.1016/j.jns.2018.08.028.

Must Reads in Movement Disorders

Tourette, CTD, and Cardiometabolic Disorders Link, JAMA Neurology; ePub 2018 Jan 14; Brander, et al

Study Compares 2 Cognitive Assessment Tools, Mov Disord; ePub 2018 Dec 10; Hendershott, et al

White Matter Differences Between ET and PD, Neurology; ePub 2018 Nov 30; Juttukonda, et al

Physical Activity and Clinical Progression in PD, Parkinsonism Relat Disord; ePub 2018 Dec 10; Amara, et al

Analyzing the Spectrum of Visual Symptoms in PD , Front Neurol; ePub 2018 Nov 27; Barrell, et al