Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Predictors of Worsening HRQL in Parkinson Disease

Parkinsonism Relat Disord; ePub 2018 Jul 2; Margolius, et al

The majority of predictors of worsening of health-related quality of life (HRQL) in Parkinson disease (PD) are baseline disease and demographic characteristics that are difficult to modify, according to a recent study. Data were collected from the National Parkinson Foundation Quality Improvement Initiative (NPF-QII) registry and HRQL was measured by the Parkinson's Disease Questionnaire-39 (PDQ-39). Researchers calculated the PDQ-39 change between every 2 consecutive visits and generated binary outcomes using the threshold for clinically meaningful change. They found:

  • Of 8,041 subjects enrolled, 5,250 had at least 1 follow-up visit and were included in the analysis.
  • Subjects were separated into 2 groups, “worse” and “not worse,” based on PDQ-39 change >1.6 across consecutive visits.
  • The “worse” group was more likely to be older, to have motor fluctuations, be on cognitive enhancers, and to have more impaired immediate 5-word recall.
  • The “non-worse” group was more likely to have rest tremor, and to utilize social work/counseling.

Margolius A, Cubillos F, He Y, Wu S, Schmidt P, Simuni T, on behalf of the NPF QII Investigators. Predictors of clinically meaningful change in PDQ-39 in Parkinson's disease. [Published online ahead of print July 2, 2018]. Parkinsonism Relat Disord. doi:10.1016/j.parkreldis.2018.06.034.

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