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Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Parkinson Patients’ Stated Goals for DBS Measured

Neurology; ePub 2017 Jan 10; Kubu, Cooper, et al

In a recent study, researchers aimed to report on data detailing the perceived benefit of deep brain stimulation (DBS) on the most commonly cited symptom and activity goals identified by patients with Parkinson disease. Improvements in patients’ individually defined goals were evident over time and that some of these improvements occurred in areas in which the benefits associated with DBS are not as well-documented. 52 participants completed a semi-structured interview soliciting their symptom and behavioral goals and corresponding visual analog scales measuring perceived symptom severity and limits to goal attainment. Severity ratings were completed prior to and at 2 times following DBS. Researchers found:

  • The most common symptom goals were improvements in tremor, gait, and nonmotor symptoms, whereas the most frequent behavioral goals related to interpersonal relationships, work, and avocational pursuits.
  • Most severity ratings were significantly correlated with each other but not with the standard clinical research (SCR) measures.
  • Significant improvements were evident on all SCR measures after DBS.


Kubu CS, Cooper SE, Machado A, Frazier T, Vitek J, Ford PJ. Insights gleaned by measuring patients' stated goals for DBS: More than tremor. [Published online ahead of print January 10, 2017]. Neurology. doi:10.1212/WNL.0000000000003485.

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