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Motor Asymmetry Over Time in PD Evaluated

J Neurol Sci; 2018 Oct 15; Miller-Patterson, et al

The lack of observed change in Unified Parkinson Disease Rating Scale (UPDRS) score difference suggests that motor symptoms in PD patients remain asymmetric. This according to a recent study that aimed to assess change in asymmetry in PD over time. Therefore, this is important to consider clinically when predicting the natural course of PD and considering alternative diagnoses. Charts of 109 consecutive patients who had been followed in a movement disorders clinic for routine PD care were retrospectively reviewed. All patients had been treated for PD symptoms and had been seen during at least 2 annual time points over 5 years. Interval absolute differences in UPDRS scores for bradykinesia, rigidity, and tremor between the right and left sides were calculated for annual time points. Researchers found:

  • Neither bradykinesia, rigidity, nor tremor became more symmetric over a 5-year period.
  • There was not a statistically significant change in asymmetry at any annual time point for these motor symptoms.

Miller-Patterson C, Buesa R, McLaughlin N, Jones R, Akbar U, Friedman JH. Motor asymmetry over time in Parkinson’s disease. J Neurol Sci. 2018;393:14-17. doi:10.1016/j.jns.2018.08.001.