Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Estrogen Exposure May Provide Protection from PSP

Mov Disord; ePub 2018 Feb 20; Park, Ilango, et al

A recent case-control study suggests a protective role of lifetime estrogen exposure in progressive supranuclear palsy (PSP). Researchers evaluated the self-reported reproductive characteristics and estrogen of 150 women with PSP and 150 age-matched female controls who participated in the Environmental Genetic-PSP study. Conditional logistic regression models were generated to examine associations of PSP with estrogen. They found:

  • There was no association between years of estrogen exposure duration and PSP.
  • There was a suggestion of an inverse association between composite estrogen score and PSP that did not reach statistical significance.
  • Any exposure to estrogen replacement therapy halved the risk of PSP.
  • Among PSP cases, earlier age at menarche was associated with better performance on Hoehn and Yahr stage and Unified Parkinson's Disease Rating Scale II score at clinical examination.

Park HK, Ilango S, Charriez CM, et al. Lifetime exposure to estrogen and progressive supranuclear palsy: Environmental and Genetic PSP study. [Published online ahead of print February 20, 2018]. Mov Disord. doi:10.1002/mds.27336.

This Week's Must Reads

Quality of Life Varies in the Early Stages of MS, Disabil Health J; ePub 2018 May 31; Strober

Molecular Signature of EBV in MS Brain Lesions, Neurol Neuroimmunol Neuroinflamm; 2018 Jul; Moreno, et al

3D-FLAIR Detects Highest Infratentorial MS Lesions, Clin Imaging; 2018 Sep-Oct; Wang, Uribe, et al

Examining the Progression of Fatigue in MS, Mult Scler; 2018 Jun; van der Vuurst de Vries, et al

Psychosocial Adjustment in People with MS, Int J MS Care; 2018 May/Jun; Grech, et al

Must Reads in Movement Disorders

Tourette Syndrome, Tic Disorders, and Education, JAMA Neurology; ePub 2018 May 29; Pérez-Vigil, et al

RLS with PLMS More Common in Elderly Persons, Sleep; ePub 2018 Jun 1; Doan, Koo, Ogilvie, et al

Predicting Alpha-Synuclein Pathology Pre-Mortem, Parkinsonism Relat Disord; ePub 2018 May 17; Shprecher, et al

Excessive Daytime Sleepiness: Early Feature of DLB , Parkinsonism Relat Disord; 2018 May; Kasanuki, et al

HIV in HD Linked with Earlier Age of Symptom Onset, J Huntingtons Dis; 2018 Jun 1; Schultz, et al