Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Earlier HD Onset, Caffeinated Soda Associated

Mov Disord; ePub 2018 Jan 3; Tanner, Marder, et al

In Huntington disease (HD), 60% of the variance in onset age is not explained by the huntingtin gene mutation, and a recent study found that HD onset was earlier among consumers of caffeinated soda, but not other caffeinated beverages. The objective of this study was to assess the relationship of lifestyle factors with motor phenoconversion among persons at risk for HD. The associations of motor phenoconversion and exposure to selected lifestyle and health factors were examined using Cox proportional hazards analyses adjusted for age, gender, and repeat length. Researchers found:

  • Of 247 participants, 36 (14.6%) phenoconverted; mean follow-up was 4.2 years.
  • Greater caffeinated soda use was associated with an increased hazard of phenoconversion: moderate use hazard ratio, 2.26, high use hazard ratio, 4.05.

Citation:

Tanner C, Marder K, Eberly S, Biglan K, Oakes D, Shoulson I, on behalf of the Huntington Study Group Prospective Huntington At-Risk Observational Study Investigators. [Published online ahead of print January 3, 2018]. Mov Disord. doi: 10.1002/mds.27239.

This Week's Must Reads

Sex Differences Evident in Cognitive Decline in PD, Parkinsonism Relat Disord; ePub 2018 Feb 9; Cholerton, et al

IBD Associated with Lower Risk of Developing PD, Parkinsonism Relat Disord; ePub 2018 Feb 9; Camacho-Soto, et al

Dysgeusia, Side Effect of DBS, Can Be Reduced, J Clin Neurosci; ePub 2018 Feb 2; Carlson, et al

Leg Stereotypy Syndrome Common in Healthy Adults, J Neuro Neurosurg Psychiatry; ePub 2018 Jan 13; Lotia, et al

Adductor Focal Laryngeal Dystonia Impacts QOL, J Clin Mov Disord; ePub 2017 Dec 13; Stewart, et al

Must Reads in Movement Disorders

Sex Differences Evident in Cognitive Decline in PD, Parkinsonism Relat Disord; ePub 2018 Feb 9; Cholerton, et al

IBD Associated with Lower Risk of Developing PD, Parkinsonism Relat Disord; ePub 2018 Feb 9; Camacho-Soto, et al

Dysgeusia, Side Effect of DBS, Can Be Reduced, J Clin Neurosci; ePub 2018 Feb 2; Carlson, et al

Leg Stereotypy Syndrome Common in Healthy Adults, J Neuro Neurosurg Psychiatry; ePub 2018 Jan 13; Lotia, et al

Adductor Focal Laryngeal Dystonia Impacts QOL, J Clin Mov Disord; ePub 2017 Dec 13; Stewart, et al