Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Depression Dissociated from Tremor Severity in ET

Parkinsonism Relat Disord; ePub 2018 Feb 18; Huey, et al

Depressive symptoms in patients with essential tremor (ET) were associated with poorer cognition and functional impairment, but not tremor severity, according to a recent study. Hence, these data do not support the hypothesis that depression in ET represents a psychological reaction to the tremor. The following measures were cross-sectionally assessed in a group of 223 subjects with ET: The Montreal Cognitive Assessment (MoCA) Scale, the Lawton Independent Activities of Daily Living (IADL) Scale, a neurologist assessment of tremor severity, and the Geriatric Depression Scale (GDS). Researchers found:

  • 20% (44) of the subjects met GDS criteria for depression (GDS ≥ 10).
  • 43% (94) of the subjects showed at least some cognitive impairment (≤24 on the MoCA), and 15.3% (34) reported significant functional impairment (IADL score < 7).
  • There was no significant association between GDS score and tremor scale score.
  • >60% of subjects who were depressed, per GDS cut-off score (≥10), were not receiving medical treatment for depression.

Citation:

Huey ED, Cosentino S, Chapman S, et al. Self-report depressive symptoms are dissociated from tremor severity in essential tremor. [Published online ahead of print February 19, 2018]. Parkinsonism Relat Disord. doi:10.1016/j.parkreldis.2018.02.031.

This Week's Must Reads

Prevalence of Asthma in Persons with MS, Mult Scler Relat Disord; ePub 2018 Dec 11; Hill, et al

Normal-Appearing White Matter in MS Examined, Neuroradiology; ePub 2018 Dec 12; Yu, et al

MS Disease Burden: Which Symptoms Matter Most?, Mult Scler Relat Disord; 2018 Oct; Barin, et al

Retinal Layer Thickness and MS Conversion Risk, Mult Scler; ePub 2018 Dec 3; Filippatou, et al

Importance of Coping and QOL in People with MS, Int J MS Care; ePub 2018 Dec 6; Grech, et al

Must Reads in Movement Disorders

Neurofilament Light Protein and Movement Disorders, JAMA Neurology; ePub 2018 Dec 3; Olsson, et al

Levodopa-Induced Dyskinesia in PD Assessed, Neurology; ePub 2018 Nov 7; Turcano, et al

Regional Brain Volumes Predict DBS Motor Response , Parkinsonism Relat Disord; ePub 2018 Nov 28; Younce, et al

Medical Decision-Making Examined in PSP, Parkinsonism Relat Disord; ePub 2018 Nov 26; Gerstenecker, et al

Cortical Dynamics Examined in Essential Tremor, Mov Disord; ePub 2018 Oct 21; Roy, Coombes, et al