Deep brain stimulation (DBS) performed with the patient under general anesthesia (GA) to treat essential tremor (ET) is as safe and effective as traditional DBS surgery with intraoperative test stimulation while the patient is under conscious sedation without GA, according to a recent study. Clinical outcomes were prospectively collected at baseline and 3-month follow-up for patients undergoing DBS surgery performed by a single surgeon. Stereotactic, euclidean, and radial errors of lead placement were calculated. Functional (activities of daily living), quality of life (Quality of Life in Essential Tremor [QUEST] questionnaire), and tremor severity outcomes were compared between groups. Researchers found:
- 56 patients underwent surgery: 16 without GA (24 electrodes) and 40 with GA (66 electrodes).
- The mean baseline functional scores and QUEST summary indices were not different between groups.
- Non-GA and GA groups did not differ significantly regarding mean postoperative percentages of functional improvement (non-GA, 47.9% vs GA, 48.1%) or QUEST summary indices (non-GA, 79.9% vs GA, 74.8%).
- Accuracy was comparable between groups (mean radial error 0.9 ± 0.3 mm for non-GA and 0.9 ± 0.4 mm for GA patients).
Chen T, Mirzadeh Z, Chapple KM, et al. Intraoperative test stimulation versus stereotactic accuracy as a surgical end point: A comparison of essential tremor outcomes after ventral intermediate nucleus deep brain stimulation. J Neurosurg. 2018;129(12):290-298. doi:10.3171/2017.3.JNS162487.
This Week's Must Reads
Fully Automated Test Gauges Processing Speed in MS, MS Mult Scler; ePub 2018 Aug 6; Patel, Shen, et al
Inflammation and Disability in Progressive-Onset MS, JAMA Neurology; ePub 2018 Aug 6; Hughes, et al
Mental Health’s Impact on Falls in Patients with MS, Mult Scler Relat Disord; ePub 2018 Jul 26; Kalron, et al
House-Call-Based Practice Viable for Advanced MS, Int J MS Care; ePub 2018 Aug 7; Healey, Zabad, et al
Detection of Chronic Active MS Lesions on 3T MRI, AJNR Am J Neuroradiol; 2018 Jul; Absinta, et al
Must Reads in Movement Disorders
Index Finger Pointing Observed in Movement Disorders, Front Neurol; ePub 2018 Jul 4; Vives-Rodriguez, et al
Contact Sports Linked with Lewy Body Pathology, J Neuropathol Exp Neurol; ePub 2018 Jul 25; Adams, et al
Predictors of Worsening HRQL in Parkinson Disease, Parkinsonism Relat Disord; ePub 2018 Jul 2; Margolius, et al
Patients with PD Having Lumbar Surgery: Greater LOS, Parkinsons Dis; ePub 2018 Jun 27; Steinberger, et al
DBS Surgery with General Anesthesia Safe, Effective , J Neurosurg; 2018 Aug; Chen, Mirzadeh, Chapple, et al