Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Comparison of Tests for Cognitive Deficits in PD

Mov Disord; ePub 2018 Sep 14; Hoogland, et al

Normed neuropsychological tests across multiple cognitive domains consistently detect cognitive deficits in Parkinson disease (PD) when compared with site‐specific healthy control (HC) performance, but relative PD performance was significantly affected by the inclusion and type of HCs vs the use of published norms only. This according to a recent investigation that sought to identify neuropsychological tests that consistently detect cognitive decline in PD across studies. Data from 30 normed neuropsychological tests across 20 international studies in up to 2,908 non-demented PD patients were analyzed. A subset of 17 tests was administered to up to 1,247 HCs. Researchers found:

  • Pooled estimates of the differences between PD and site‐specific healthy controls identified significant cognitive deficits in PD patients on 14 test scores across 5 commonly assessed cognitive domains (attention or working memory, executive, language, memory, and visuospatial abilities), but HC performance was statistically above average on 7 of these tests.
  • Analyses based on published norms only, as opposed to direct assessment of healthy controls, showed high between‐study variability that could not be accounted for and led to inconclusive results.


Hoogland J, van Wanrooij LL, Boel JA, et al, on behalf of the IPMDS Study Group Validation of Mild Cognitive Impairment in Parkinson Disease. Detecting mild cognitive deficits in Parkinson's disease: Comparison of neuropsychological tests. [Published online ahead of print September 14, 2018]. Mov Disord. doi:10.1002/mds.110.

This Week's Must Reads

Vegetable/Fruit Intake Benefits Cognitive Function, Neurology; ePub 2018 Nov 21; Yuan, Fondell, et al

Alzheimer Dementia and Age-Related Neuropathologies, Ann Neurol; ePub 2018 Nov 12; Boyle, Yu, et al

Kidney Function and Post-Stroke Mortality Examined, Stroke; ePub 2018 Nov 9; El Husseini, Fonarow, et al

Meditation May Help to Alleviate US Stroke Burden, J Stroke Cerebrovasc Dis; ePub 2018 Nov 24; Ambavane, et al

Must Reads in Movement Disorders

Cortical Dynamics in Essential Tremor Examined, Mov Disord; ePub 2018 Oct 21; Roy, et al

Distinguishing PD from PSP Through Biomarker, J Parkinsons Dis; 2018 Oct; Bottero, et al

Self-Reported Activity in Veterans with PD is Low, Parkinsonism Relat Disord; ePub 2018 Oct 23; Mantri, et al

End-Of-Life Experiences in Dementia with Lewy Bodies, J Am Geriatr Soc; ePub 2018 Oct 6; Armstrong, et al

First-Degree Kin of Patients with ET and Cognition, Parkinsonism Relat Disord; ePub 2018 Oct 30; Meyers, et al