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Climbing Fiber Pathology Across ET Subtypes

Parkinsonism Relat Disord; ePub 2018 Feb 19; Lee, et al

Changes in the distribution of climbing fiber-Purkinje cell (CF-PC) synapses are broadly part of the neurodegenerative process in the essential tremor (ET) cerebellum, a recent study found. Researchers studied 2 CF-PC synaptic pathologies (CF synaptic density and percentage of CFs in the parallel fiber [PF] territory) in the cerebella of 60 ET cases with a range of clinical presentations and 30 age-matched controls. They found:

  • Compared to controls, ET cases had lower CF synaptic density and a higher percentage of CFs in the PF territory.
  • ET cases with tremor onset <50 years and tremor onset ≥50 years did not differ significantly with respect to CF synaptic density and percentage of CFs in the PF territory.
  • Similar results were found when comparing familial vs sporadic ET cases, and ET cases with head tremor vs those without head tremor.
  • Among all ET cases, lower CF synaptic density was associated with lower PC counts and higher torpedo counts.
  • In addition, higher percentage of CFs in the PF territory was associated with lower PC counts and higher torpedo counts.
Citation:

Lee D, Gan S-R, Faust PL, Louis ED, Kuo S-H. Climbing fiber-Purkinje cell synaptic pathology across essential tremor subtypes. [Published online ahead of print February 19, 2018]. Parkinsonism Relat Disord. doi:10.1016/j.parkreldis.2018.02.032

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