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Caffeine Drinking in Relatives of Patients with ET

Neuroepidemiol; ePub 2018 Jun 28; Louis, et al

The balance of caffeinated to decaffeinated beverages is different in unaffected first-degree relatives of essential tremor cases (FD-ET) than controls, a recent study found. Caffeine can exacerbate tremor and FD-ET often have mild, subclinical tremor. This study sought to discover whether relatives of ET cases modify their caffeine consumption before disease onset. Researchers ascertained the patterns of coffee and tea intake using a structured questionnaire, and compared the use in FD-ET to the use in age-matched controls. 3 measures of relative caffeinated coffee + tea to decaffeinated coffee + tea were constructed. There were 263 individuals (190 FD-ET, 73 controls). Caffeine index 1 = (cups of caffeinated coffee + tea) – (cups of decaffeinated coffee + tea) consumed on the day of evaluation. Caffeine index 2 = (cups of caffeinated coffee + tea) – (cups of decaffeinated coffee + tea) consumed in a typical month. They found:

  • Caffeine index 1 in FD-ET was less than 1-half that of controls.
  • Caffeine index 2 was similarly lower in FD-ET than controls.
  • The percentage of coffee and tea that was caffeinated in a typical month was also significantly lower in FD-ET than controls.
Citation:

Louis ED, Meyers JH, Cristal AD, Factor-Litvak P. Caffeine consumption in first-degree relatives of essential tremor cases: Evidence of dietary modification before disease onset. [Published online ahead of print June 28, 2018]. Neuroedpidemiol. doi:10.1159/000489960.

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Must Reads in Movement Disorders

Cortical Dynamics in Essential Tremor Examined, Mov Disord; ePub 2018 Oct 21; Roy, et al

Distinguishing PD from PSP Through Biomarker, J Parkinsons Dis; 2018 Oct; Bottero, et al

Self-Reported Activity in Veterans with PD is Low, Parkinsonism Relat Disord; ePub 2018 Oct 23; Mantri, et al

End-Of-Life Experiences in Dementia with Lewy Bodies, J Am Geriatr Soc; ePub 2018 Oct 6; Armstrong, et al

First-Degree Kin of Patients with ET and Cognition, Parkinsonism Relat Disord; ePub 2018 Oct 30; Meyers, et al