Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Caffeine Drinking in Relatives of Patients with ET

Neuroepidemiol; ePub 2018 Jun 28; Louis, et al

The balance of caffeinated to decaffeinated beverages is different in unaffected first-degree relatives of essential tremor cases (FD-ET) than controls, a recent study found. Caffeine can exacerbate tremor and FD-ET often have mild, subclinical tremor. This study sought to discover whether relatives of ET cases modify their caffeine consumption before disease onset. Researchers ascertained the patterns of coffee and tea intake using a structured questionnaire, and compared the use in FD-ET to the use in age-matched controls. 3 measures of relative caffeinated coffee + tea to decaffeinated coffee + tea were constructed. There were 263 individuals (190 FD-ET, 73 controls). Caffeine index 1 = (cups of caffeinated coffee + tea) – (cups of decaffeinated coffee + tea) consumed on the day of evaluation. Caffeine index 2 = (cups of caffeinated coffee + tea) – (cups of decaffeinated coffee + tea) consumed in a typical month. They found:

  • Caffeine index 1 in FD-ET was less than 1-half that of controls.
  • Caffeine index 2 was similarly lower in FD-ET than controls.
  • The percentage of coffee and tea that was caffeinated in a typical month was also significantly lower in FD-ET than controls.
Citation:

Louis ED, Meyers JH, Cristal AD, Factor-Litvak P. Caffeine consumption in first-degree relatives of essential tremor cases: Evidence of dietary modification before disease onset. [Published online ahead of print June 28, 2018]. Neuroedpidemiol. doi:10.1159/000489960.

This Week's Must Reads

Readmission Rates After Thrombectomy for Stroke , J Stroke Cerebrovasc Dis; ePub 2018 Jul 3; Ramchand, et al

Admissions for Psychotic Episodes, Epilepsy Linked , Epilepsia; ePub 2018 Jul 4; Rossi, Kim, et al

Gender and Cognition in Overweight Adults with T2D, Alzheimers Dement; ePub 2018 Jul 4; Espeland, et al

Subjective Improvements in Sleep Apnea Examined, Sleep Med; ePub 2018 Jul 4; Bhat, Gupta, et al

FDA Approves Xeomin for Excessive Drooling, Merz North America news release; 2018 Jul 3

Must Reads in Movement Disorders

FDA Approves Xeomin for Excessive Drooling, Merz North America news release; 2018 Jul 3

Predicting Falls in Patients with Parkinson Disease, Neurol Clin Pract; 2018 Jun 1; Parashos, et al

A Rare Form of Lewy Body Disease Examined, Neurology; ePub 2018 Jun 13; Kasanuki, et al

Caffeine Drinking in Relatives of Patients with ET, Neuroepidemiol; ePub 2018 Jun 28; Louis, et al

National Analysis of DBS Rates, Causes, and Outcomes, Clin Neurol Neurosurg; 2018 Aug; Rumalla, et al