Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Caffeine Drinking in Relatives of Patients with ET

Neuroepidemiol; ePub 2018 Jun 28; Louis, et al

The balance of caffeinated to decaffeinated beverages is different in unaffected first-degree relatives of essential tremor cases (FD-ET) than controls, a recent study found. Caffeine can exacerbate tremor and FD-ET often have mild, subclinical tremor. This study sought to discover whether relatives of ET cases modify their caffeine consumption before disease onset. Researchers ascertained the patterns of coffee and tea intake using a structured questionnaire, and compared the use in FD-ET to the use in age-matched controls. 3 measures of relative caffeinated coffee + tea to decaffeinated coffee + tea were constructed. There were 263 individuals (190 FD-ET, 73 controls). Caffeine index 1 = (cups of caffeinated coffee + tea) – (cups of decaffeinated coffee + tea) consumed on the day of evaluation. Caffeine index 2 = (cups of caffeinated coffee + tea) – (cups of decaffeinated coffee + tea) consumed in a typical month. They found:

  • Caffeine index 1 in FD-ET was less than 1-half that of controls.
  • Caffeine index 2 was similarly lower in FD-ET than controls.
  • The percentage of coffee and tea that was caffeinated in a typical month was also significantly lower in FD-ET than controls.
Citation:

Louis ED, Meyers JH, Cristal AD, Factor-Litvak P. Caffeine consumption in first-degree relatives of essential tremor cases: Evidence of dietary modification before disease onset. [Published online ahead of print June 28, 2018]. Neuroedpidemiol. doi:10.1159/000489960.

This Week's Must Reads

Examining Brain Markers for Late-Onset Epilepsy, Neurology; ePub 2019 Jan 25; Johnson, et al

Hearing Loss Linked Cognitive Decline Risk in Men, Alzheimers Dement; ePub 2019 Jan 29; Curhan, et al

Brain Cholesterol Metabolism and PD Examined, Mov Disord; ePub 2019 Jan 25; Huang, et al

Sleep Behavior Disorder, Clinical Progression in PD, Parkinsonism Relat Disord; ePub 2019 Jan 29; Duarte Folle, et al

Spontaneous Subarachnoid Hemorrhage During Pregnancy, J Stroke Cerebrovasc Dis; ePub 2019 Jan 30; Limaye, et al

Must Reads in Movement Disorders

Tourette, CTD, and Cardiometabolic Disorders Link, JAMA Neurology; ePub 2018 Jan 14; Brander, et al

Study Compares 2 Cognitive Assessment Tools, Mov Disord; ePub 2018 Dec 10; Hendershott, et al

White Matter Differences Between ET and PD, Neurology; ePub 2018 Nov 30; Juttukonda, et al

Physical Activity and Clinical Progression in PD, Parkinsonism Relat Disord; ePub 2018 Dec 10; Amara, et al

Analyzing the Spectrum of Visual Symptoms in PD , Front Neurol; ePub 2018 Nov 27; Barrell, et al