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Autonomic Dysfunction in PD and Its Effect on QOL

Mov Disord; ePub 2017 Dec 26; Merola, et al

The severity of autonomic symptoms in patients with Parkinson disease (PD) progressed by 20% over 1 year and was independently associated with impairments in daily living activities and health-related quality of life, a recent study found. Researchers recruited 131 consecutive patients into a 12-month, prospective, observational cohort study. Clinical measures included the International Parkinson and Movement Disorder Society/UPDRS, the Scale for Outcomes in Parkinson Disease-Autonomic, the Orthostatic Hypotension Symptoms Assessment, and orthostatic blood pressure measurements. They found:

  • The overall severity of autonomic symptoms, as measured by the Orthostatic Hypotension Symptoms Assessment total score, worsened by 20% over 12 months, with an overall increase in orthostatic hypotension prevalence from 31.1% to 46.7%.
  • Worsening of autonomic symptoms was independently associated with deterioration in daily living activities and health-related quality of life adjusting for disease duration, cognitive impairment, and motor severity.
  • Regardless of symptomatic status, orthostatic hypotension was associated with greater deterioration in daily living activities, health care utilization, and falls, compared to patients without orthostatic hypotension.
Citation:

Merola A, Romagnolo A, Rosso M, et al. Autonomic dysfunction in Parkinson's disease: A prospective cohort study. [Published online ahead of print December 26, 2017]. Mov Disord. doi: 10.1002/mds.27268.

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