Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Antipsychotic Use in PD Lower than Expected

Mov Disord; ePub 2017 Dec 26; Bower, et al

The prevalence of antipsychotic use in patients with Parkinson disease (PD) is lower than expected from previously reported cumulative incidences, according to a recent study. Dementia is highly prevalent in those starting antipsychotics and most of the patients on antipsychotics had a reasonable risk-benefit ratio for taking them. Researchers used the medical records-linkage system of the Rochester Epidemiology Project to study the use of antipsychotic medication in all persons with PD (n=296) in Olmsted County, MN, on January 1, 2006. They found:

  • The overall prevalence of antipsychotic use was 9.8% (29 of 296); 95.5% (28 of 29) of the patients had dementia when initiating antipsychotics.
  • The most frequent indication (71.4%; 20 of 28) was psychosis or behavior threatening to the patient or others.


Bower JH, Grossardt BR, Rocca WA, Savica R. Prevalence of and indications for antipsychotic use in Parkinson's disease. [Published online ahead of print December 26, 2017]. Mov Disord. doi:10.1002/mds.27256.

This Week's Must Reads

Hospital Readmission After Seizure Discharge, Neurology; ePub 2018 Dec 21; Blank, et al

VP Shunts and Post-Operative Complications Assessed, J Stroke Cerebrovasc Dis; ePub 2018 Dec 20; Linzey, et al

Disparities in Inter-Hospital Helicopter Transport, J Stroke Cerebrovasc Dis; ePub 2018 Dec 11; Sarrazin, et al

Mild-to-Moderate OSA Linked with Hypertension, Sleep; ePub 2018 Dec 22; Vgontzas, et al

Aspirin Reduces Stroke Risk in Women with Prior HDP, Neurology; ePub 2018 Dec 26; Miller, Boehme, et al

Must Reads in Movement Disorders

Study Compares 2 Cognitive Assessment Tools, Mov Disord; ePub 2018 Dec 10; Hendershott, et al

White Matter Differences Between ET and PD, Neurology; ePub 2018 Nov 30; Juttukonda, et al

Physical Activity and Clinical Progression in PD, Parkinsonism Relat Disord; ePub 2018 Dec 10; Amara, et al

Analyzing the Spectrum of Visual Symptoms in PD , Front Neurol; ePub 2018 Nov 27; Barrell, et al

Treadmill Walking Improved Forward Walking in PD, J Neurol Phys Ther; 2019 Jan; Rawson, McNeely, et al