Clinical Edge

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Antipsychotic Use in PD Lower than Expected

Mov Disord; ePub 2017 Dec 26; Bower, et al

The prevalence of antipsychotic use in patients with Parkinson disease (PD) is lower than expected from previously reported cumulative incidences, according to a recent study. Dementia is highly prevalent in those starting antipsychotics and most of the patients on antipsychotics had a reasonable risk-benefit ratio for taking them. Researchers used the medical records-linkage system of the Rochester Epidemiology Project to study the use of antipsychotic medication in all persons with PD (n=296) in Olmsted County, MN, on January 1, 2006. They found:

  • The overall prevalence of antipsychotic use was 9.8% (29 of 296); 95.5% (28 of 29) of the patients had dementia when initiating antipsychotics.
  • The most frequent indication (71.4%; 20 of 28) was psychosis or behavior threatening to the patient or others.


Bower JH, Grossardt BR, Rocca WA, Savica R. Prevalence of and indications for antipsychotic use in Parkinson's disease. [Published online ahead of print December 26, 2017]. Mov Disord. doi:10.1002/mds.27256.

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